Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation

被引：19

作者：

Storek, J

Dawson, MA

Maloney, DG

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[2] Univ Washington, Seattle, WA 98195 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2003年 / 9卷 / 12期

关键词：

T cells; naive; blood stem cell allografts; hematopoietic cell transplantation; BONE-MARROW-TRANSPLANTATION; THYMIC FUNCTION; RECONSTITUTION; ADULTS; AGE;

D O I：

10.1016/j.bbmt.2003.09.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Naive T cells after allogeneic hematopoietic cell transplantation are thought to originate from the engrafted hematopoietic cells. In this report, we show that there is a correlation between the number of naive CD4 T cells infused with peripheral blood stem cell grafts and the absolute number of peripheral naive CD4 T cells on day 30 (R = 0.65; P < .001), day 80 (R = 0.63; P < .001), and day 180 (R = 0.66; P < .001) after transplantation. These results suggest that in the first 6 months after transplantation, most naive CD4 T cells are derived from the naive T cells infused with the graft. (C) 2003 American Society for Blood and Marrow Transplantation.

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收藏

页码：781 / 784

页数：4

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