Immunomodulatory role of prolactin in diabetes development

被引：48

作者：

Cejkova, P. ^{[1
,2
]}

Fojtikova, M. ^{[3
]}

Cerna, M. ^{[1
,2
]}

机构：

[1] Charles Univ Prague, Inst Gen Biol & Genet, Fac Med 3, Prague 10000 10, Czech Republic

[2] Charles Univ Prague, Inst Biochem Cell & Mol Biol, Dept Cell & Mol Biol, Fac Med 3, Prague 10000 10, Czech Republic

[3] Inst Rheumatol, Prague, Czech Republic

来源：

AUTOIMMUNITY REVIEWS | 2009年 / 9卷 / 01期

关键词：

Prolactin; Immunity; Monocytes; T1D; T2D; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INSULIN-RESISTANCE; AUTOIMMUNE-DISEASES; SIGNAL TRANSDUCER; DENDRITIC CELLS; GROWTH-HORMONE; T-CELLS; EXPRESSION; RECEPTOR; LYMPHOCYTES;

D O I：

10.1016/j.autrev.2009.02.031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Pituitary hormone and cytokine prolactin (PRL) is one of the mediators of the bidirectional communication between neuroendocrine and immune systems. It participates in many immunomodulatory activities, affects differentiation and maturation of both, B and T lymphocytes and enhances inflammatory responses and production of immunoglobulins. Hyperprolactinemia has been described in many autoimmune diseases, both systemic (SLE, RA, PsA) and organ-specific (T1D, CD and others) and the activity of PRL has been intensively studied. Nevertheless, no data on PRL contribution to pathogenesis of diabetes mellitus is available, although the effect of PRL on beta cells of the pancreas and insulin secretion has been observed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：23 / 27

页数：5

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