Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense

被引：72

作者：

Ding, Qiuying ^{[1
]}

Yang, Dan ^{[1
]}

Zhang, Wenna ^{[1
]}

Lu, Yongming ^{[1
]}

Zhang, Mingzhu ^{[1
]}

Wang, Liming ^{[1
]}

Li, Xuehui ^{[1
]}

Zhou, Liyuan ^{[1
]}

Wu, Qingxi ^{[1
]}

Pan, Wenjuan ^{[1
]}

Chen, Yan ^{[1
]}

机构：

[1] Anhui Univ, Sch Life Sci, Key Lab Ecol Engn & Biotechnol Anhui Prov, Hefei 230601, Anhui, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2016年 / 85卷

基金：

中国国家自然科学基金;

关键词：

Antioxidant activity; Anti-aging activity; Tricholoma lobayense polysaccharide TLH-3; INDUCED CELL-DAMAGE; OXIDATIVE STRESS; EXTRACTS; PURIFICATION; APOPTOSIS; MICE;

D O I：

10.1016/j.ijbiomac.2015.12.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Polysaccharides from edible fungi usually exhibit many bioactivities. Our previous studies found that polysaccharide TLH-3 extracted from Tricholoma lobayense possessed noticeable antioxidant activity. To further explore its biological activities, the antioxidant and anti-aging activities of TLH-3 were evaluated in vitro and in vivo. The results of antioxidant activity in vitro showed that TLH-3 could enhance the cell viability, reduce the production of reactive oxygen species (ROS) and inhibit oxidative damage induced by tert-butylhydroperoxide (t-BHP) in human embryonic lung fibroblasts (HELF) cells. The anti-aging capability was measured in D-galactose (D-gal)-induced aged mice model, and the experimental data showed that TLH-3 significantly inhibited the formation of malondialdehyde (MDA) and raised the activities of superoxide dismutase (SOD) and catalase (CAT) in mice liver and serum (p < 0.05). This study suggested that TLH-3 possessed apparent antioxidant and anti-aging activities and could be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases in humans. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：133 / 140

页数：8

共 42 条

[1]

Annexin I is an endogenous ligand that mediates apoptotic cell engulfment [J].