Independent relationship of serum uric acid levels with leukocytes and coronary atherosclerotic burden

Background and Aim: Epidemiological studies have shown that increased serum uric acid (SUA) level is associated with coronary artery disease (CAD). Leukocytes have been shown to play an important role in the atherosclerotic process. The aim of the study was to investigate whether there is any relationship among SUA, leukocyte counts and coronary atherosclerotic burden in patients who are suspected of having CAD. Method and results: We enrolled 690 eligible patients who had undergone coronary angiography between October 2005 and June 2006 in a consecutive manner. The relationship of SUA with total and differential leukocyte counts and CAD was investigated. Serum uric acid levels (5.57 +/- 1.64 vs 4.63 +/- 1.27 mg/dl, p < 0.001) and leukocytes were higher in patients with CAD than those with normal coronary arteries (NCA). When we divided the patients into four groups according to the quartiles of SUA, we found that the monocyte count was prominently related with SUA (478 +/- 165, 553 +/- 177, 565 +/- 199 and 607 +/- 229 MM-3, Q1-Q4, p < 0.001). In multivariate analysis, SUA was an independent predictor of CAD (OR, 1.270; 95% CI, 1.087-1.484, p = 0.003). When we performed multiple linear regression analyses to determine the independent predictors of inflammatory cells in blood, we found a strong, positive and independent relationship between SUA with neutrophils SE: 206 60, p = 0.001) and monocytes (beta +/- SE: 35 +/- 7, p < 0.001). Conclusion: Our study results demonstrated that neutrophils and monocytes which play an important rote in inflammation and atherosclerosis were independently related with SUA. This finding suggests an important epiclemiotogic relation and may provide a possible causative mechanism of SUA in atherosclerotic process. (C) 2009 Elsevier B.V. All rights reserved.