Podocyte Detachment in Type 2 Diabetic Nephropathy

被引：34

作者：

Weil, E. Jennifer ^{[1
]}

Lemley, Kevin V. ^{[2
]}

Yee, Berne ^{[3
]}

Lovato, Tracy ^{[1
]}

Richardson, Meghan ^{[1
]}

Myers, Bryan D. ^{[4
]}

Nelson, Robert G. ^{[1
]}

机构：

[1] NIDDK, NIH, Phoenix, AZ 85014 USA

[2] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Divi Nephrol,Dept Pediat, Los Angeles, CA 90033 USA

[3] SW Kidney Inst, Phoenix, AZ USA

[4] Stanford Univ, Sch Med, Div Nephrol, Stanford, CA 94305 USA

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 2011年 / 33卷

关键词：

Diabetic kidney disease; Electron microscopy; Histology; Morphometry; Podocyte; GLOMERULOSCLEROSIS; PROTEINURIA; EXCRETION; MELLITUS; DISEASE; INJURY;

D O I：

10.1159/000327047

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Background: Glomerular podocyte number declines and urinary excretion of podocytes increases as kidney disease progresses in persons with type 2 diabetes mellitus (T2DM). Methods: Using high-power electron microscopy, we quantified podocyte detachment in T2DM. Results: We evaluated 106 glomeruli (range 1-6 per subject) from 40 Pima Indian subjects with T2DM enrolled in a clinical trial. On high-power electron micrographs, 35% of the subjects had no evidence of podocyte detachment. Among the remaining subjects, the median percentage of basement membrane with podocyte detachment was 0.62% (interquartile range = 0.32-1.52%). Conclusion: Podocyte detachment from the glomerular basement membrane has been described and measured in type 1 diabetes mellitus using a different method. We now document podocyte detachment microscopically and quantify it morphometrically in humans with T2DM. The findings offer quantitative histologic support to a potential mechanism for the functional impairment, and possibly the sclerosis of glomeruli, in diabetic glomerular injury. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：21 / 24

页数：4

共 12 条

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[2]

Proteinuria in diabetic kidney disease: A mechanistic viewpoint [J].