Stability of phosphorothioate oligonucleotides in aqueous ammonia in presence of stainless steel

被引：8

作者：

Turney, BJ ^{[1
]}

Cheruvallath, ZS ^{[1
]}

Andrade, M ^{[1
]}

Cole, DL ^{[1
]}

Ravikumar, VT ^{[1
]}

机构：

[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1999年 / 18卷 / 01期

关键词：

D O I：

10.1080/07328319908045596

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligodeoxyribonucleotide phosphorothioates undergo desulfurization in presence of metal in aqueous ammonia at elevated temperatures. The extent of sulfur loss and chain cleavage have been investigated.

引用

页码：89 / 93

页数：5

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