The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5

被引：4

作者：

Aiba, T

Kohu, K

Ishidao, T

Yasui, N

Horii, A

Aburatani, H

Akiyama, T

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Lab Mol & Genet Informat, Bunkyo Ku, Tokyo 1130032, Japan

[2] Tohoku Univ, Sch Med, Dept Mol Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[3] Univ Tokyo, Genome Sci Div, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 337卷 / 01期

关键词：

tumor suppressor; discs large; dig; scaffolding protein; MAGUK; Scyb5; microarray;

D O I：

10.1016/j.bbrc.2005.09.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian homolog of the Drosophila discs large tumor suppressor protein Dig functions as a scaffolding protein that facilitates the transmission of diverse signals. In the present study, we attempted to identify the downstream target genes of Dig, and found that Dig up-regulates expression of the ELR+ CXC chemokine Scyb5, which has been implicated in the immune system. Our finding suggests that Scyb5 may play an important role in the tumor suppressor function of Dig. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：191 / 194

页数：4

共 27 条

[1] Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors [J].