Insulin-like growth factors as mediators of functional plasticity in the adult brain

Insulin-like growth factors (IGFs) are present in the brain throughout life. While their role as modulators of brain growth and differentiation during development is becoming apparent, their possible involvement in adult brain function is less known. Nevertheless, accumulating evidence indicates a role for ICFs in brain plasticity processes. Specifically, ICFs modulate synaptic efficacy by regulating synapse formation, neurotransmitter release and neuronal excitability. ICFs also provide constant trophic support to target cells in the brain and in this way maintain appropriate neuronal function. Pathological dearrangement of this trophic input may lead to brain disease. Molecular targets of the IGFs in the adult brain may include pre- and postsynaptic proteins involved in synaptic contacts, membrane channels, neurite-guiding molecules, extracellular matrix components and glial-derived intercellular messengers. Future studies on the role of ICFs in the adult brain may help unravel the relationship between neuronal plasticity and brain disease.