2018 Joint European consensus document on the management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous cardiovascular interventions: a joint consensus document of the European Heart Rhythm Association (EHRA), European Society of Cardiology Working Group on Thrombosis, European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA)

被引：229

作者：

Lip, Gregory Y. H. ^{[1
,2
,3
,4
]}

Collet, Jean-Phillippe ^{[5
]}

Haude, Michael ^{[6
]}

Byrne, Robert ^{[7
,8
]}

Chung, Eugene H. ^{[9
]}

Fauchier, Laurent ^{[10
]}

Halvorsen, Sigrun ^{[11
,12
]}

Lau, Dennis ^{[13
,14
]}

Lopez-Cabanillas, Nestor ^{[15
,16
]}

Lettino, Maddalena ^{[16
]}

Marin, Francisco ^{[17
]}

Obel, Israel ^{[18
]}

Rubboli, Andrea ^{[19
]}

Storey, Robert F. ^{[20
]}

Valgimigli, Marco ^{[21
]}

Huber, Kurt ^{[22
]}

Potpara, Tatjana ^{[23
]}

Lundqvist, Carina Blomstrom ^{[24
]}

Crijns, Harry ^{[25
]}

Steffel, Jan ^{[26
]}

Heidbuchel, Hein ^{[27
,28
]}

Stankovic, Goran ^{[29
]}

Airaksinen, Juhani ^{[30
]}

Ten Berg, Jurrien M. ^{[31
]}

Capodanno, Davide ^{[32
]}

James, Stefan ^{[33
,34
]}

Bueno, Hector ^{[35
,36
]}

Morais, Joao ^{[37
]}

Sibbing, Dirk ^{[38
]}

Rocca, Bianca ^{[39
]}

Hsieh, Ming-Hsiung ^{[40
]}

Akoum, Nazem ^{[41
]}

Lockwood, Deborah J. ^{[42
]}

Gomez Flores, Jorge Rafael ^{[43
]}

Jardine, Ronald ^{[44
]}

机构：

[1] Univ Birmingham, Inst Cardiovasc Sci, Birmingham, W Midlands, England

[2] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England

[3] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[4] Aalborg Univ, Aalborg Thrombosis Res Unit, Dept Clin Med, Aalborg, Denmark

[5] Sorbonne Univ Paris 6, Hop Pitie Salpetriere, AP HP, ACTION Study Grp,Inst Cardiol,INSERM,UMRS, Paris, France

[6] Stadtische Kliniken Neuss Lukaskrankenhaus Gmbh, Kardiol, Nephrol, Pneumol, Neuss, Germany

[7] Deutsch Herzzentrum Munich, Munich, Germany

[8] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany

[9] Univ N Carolina, Med, Cardiol, Electrophysiol, Chapel Hill, NC 27515 USA

[10] Univ Tours, CHU Trousseau, Fac Med, Tours, France

[11] Univ Oslo, Oslo Univ Hosp Ulleval, Dept Cardiol, Oslo, Norway

[12] Univ Oslo, Inst Clin Med, Oslo, Norway

[13] Univ Adelaide, South Australian Hlth & Med Res Inst, Ctr Heart Rhythm Disorders, Adelaide, SA, Australia

[14] Royal Adelaide Hosp, Adelaide, SA, Australia

[15] Clin Adventista Belgrano, Inst Del Corazon, Buenos Aires, DF, Argentina

[16] Humanitas Res Hosp, Cardiol Dept, Rozzano, MI, Italy

[17] Hosp Univ Virgen Arrixaca, Dept Cardiol, Murcia, Spain

[18] Milpark Hosp, Cardiol Unit, Johannesburg, South Africa

[19] Osped Maggiore Bologna, Lab Intervent Cardiol, Div Cardiol, Bologna, Italy

[20] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

[21] Inselspital Bern, Cardiol, Bern, Switzerland

[22] Wilhelminenhosp Vienna, Dept Med Cardiol & Intens Care Med 3, Vienna, Austria

[23] Univ Belgrade, Sch Med, Clin Ctr Serbia, Cardiol Clin, Belgrade, Serbia

[24] Uppsala Univ, Dept Med Sci & Cardiol, Uppsala, Sweden

[25] Maastricht UMC, Cardiol Dept, Maastricht, Netherlands

[26] Univ Heart Ctr Zurich, Zurich, Switzerland

[27] Antwerp Univ, Antwerp, Belgium

[28] Univ Hosp, Antwerp, Belgium

[29] Clin Ctr Serbia, Dept Cardiol, Belgrade, Serbia

[30] Turku Univ Hosp, Dept Internal Med, Cardiol, Turku, Finland

[31] St Antonius Hosp, Cardiol Dept, Nieuwegein, Netherlands

[32] Univ Catania, Policlin Vittorio Emanuele, Azienda Osped Univ, Ferrarotto Hosp,Cardiol Dept, Catania, Italy

[33] Uppsala Univ, Univ Uppsala Hosp, Dept Med Sci, Uppsala, Sweden

[34] Uppsala Univ, Univ Uppsala Hosp, Uppsala Clin Res Ctr, Uppsala, Sweden

[35] Melchor Fernandez Almagro, CNIC, Madrid, Spain

[36] Hosp Univ 12 Octubre, Dept Cardiol, Madrid, Spain

[37] Leiria Hosp Ctr, Dept Cardiol, Leiria, Portugal

[38] LMU, Oberarzt Med Klin & Poliklin 1, Campus Grosshadern, Munich, Germany

[39] Catholic Univ, Sch Med, Dept Pharmacol, Rome, Italy

[40] Taipei Med Univ, Taipei, Taiwan

[41] Univ Washington, Cardiol Dept, Seattle, WA 98195 USA

[42] OU Hlth Sci Ctr, OU Heart Rhythm Inst, Oklahoma City, OK USA

[43] Inst Nacl Cardiol I Chavez, Electrofisiol, Mexico City, DF, Mexico

[44] Linmed Hosp, Benoni, South Africa

来源：

EUROPACE | 2019年 / 21卷 / 02期

关键词：

European Heart Rhythm Association; Consensus document; Position paper; Atrial fibrillation; Acute coronary syndrome; Coronary artery disease; Myocardial infarction; Percutaneous coronary intervention; Stent; Antithrombotic therapy; Antiplatelet agents; Anticoagulation; Vitamin K antagonists; Non-vitamin K antagonist oral anticoagulants; Low molecular weight heparin; Parenteral anticoagulants; Left atrial appendage occlusion; Stroke; Thromboembolism; Thrombosis; Bleeding; AORTIC-VALVE IMPLANTATION; ACUTE MYOCARDIAL-INFARCTION; DUAL ANTIPLATELET THERAPY; BLEEDING RISK SCORES; VITAMIN-K ANTAGONIST; ST-SEGMENT ELEVATION; HAS-BLED SCORES; UNINTERRUPTED ORAL ANTICOAGULATION; ELUTING STENT IMPLANTATION; BARE-METAL STENTS;

D O I：

10.1093/europace/euy174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 2014, a joint consensus document dealing with the management of antithrombotic therapy in atrial fibrillation (AF) patients presenting with acute coronary syndrome (ACS) and/or undergoing percutaneous coronary or valve interventions was published, which represented an effort of the European Society of Cardiology Working Group on Thrombosis, European Heart Rhythm Association (EHRA), European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS) and Asia-Pacific Heart Rhythm Society (APHRS). Since publication of this document, additional data from observational cohorts, randomized controlled trials, and percutaneous interventions as well as new guidelines have been published. Moreover, new drugs and devices/interventions are also available, with an increasing evidence base. The approach to managing AF has also evolved towards a more integrated or holistic approach. In recognizing these advances since the last consensus document, EHRA, WG Thrombosis, EAPCI, and ACCA, with additional contributions from HRS, APHRS, Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA), proposed a focused update, to include the new data, with the remit of comprehensively reviewing the available evidence and publishing a focused update consensus document on the management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing percutaneous coronary or valve interventions, and providing up-to-date consensus recommendations for use in clinical practice.

引用

页码：192 / +

页数：27

共 183 条

[1] Transcatheter Aortic-Valve Replacement with a Self-Expanding Prosthesis [J].

Adams, David H. ;

Popma, Jeffrey J. ;

Reardon, Michael J. ;

Yakubov, Steven J. ;

Coselli, Joseph S. ;

Deeb, G. Michael ;

Gleason, Thomas G. ;

Buchbinder, Maurice ;

Hermiller, James, Jr. ;

Kleiman, Neal S. ;

Chetcuti, Stan ;

Heiser, John ;

Merhi, William ;

Zorn, George ;

Tadros, Peter ;

Robinson, Newell ;

Petrossian, George ;

Hughes, G. Chad ;

Harrison, J. Kevin ;

Conte, John ;

Maini, Brijeshwar ;

Mumtaz, Mubashir ;

Chenoweth, Sharla ;

Oh, Jae K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (19) :1790-1798

[2] Apixaban vs. warfarin with concomitant aspirin in patients with atrial fibrillation: insights from the ARISTOTLE trial [J].

Alexander, John H. ;

Lopes, Renato D. ;

Thomas, Laine ;

Alings, Marco ;

Atar, Dan ;

Aylward, Philip ;

Goto, Shinya ;

Hanna, Michael ;

Huber, Kurt ;

Husted, Steen ;

Lewis, Basil S. ;

McMurray, John J. V. ;

Pais, Prem ;

Pouleur, Hubert ;

Steg, Philippe Gabriel ;

Verheugt, Freek W. A. ;

Wojdyla, Daniel M. ;

Granger, Christopher B. ;

Wallentin, Lars .

EUROPEAN HEART JOURNAL, 2014, 35 (04) :224-232

[3] Management and outcomes of patients presenting with STEMI by use of chronic oral anticoagulation: results from the GRACE registry [J].

Alonso, Alvaro ;

Gore, Joel M. ;

Awad, Hamza H. ;

Quill, Ann L. ;

Montalescot, Gilles ;

van de Werf, Frans ;

Gulba, Dietrich C. ;

Fox, Keith A. A. ;

Eagle, Kim A. ;

Granger, Christopher B. ;

Wyman, Allison ;

Steg, Ph Gabriel .

EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 2013, 2 (03) :280-291

[4] Management and outcomes of patients presenting with sepsis and septic shock to the emergency department during nursing handover: a retrospective cohort study [J].

Alsolamy, Sami ;

Al-Sabhan, Atheer ;

Alassim, Najla ;

Sadat, Musharaf ;

Al Qasim, Eman ;

Tamim, Hani ;

Arabi, Yaseen M. .

BMC EMERGENCY MEDICINE, 2018, 18

[5] Comparison of the CHADS2, CHA2DS2 -VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: The AMADEUS trial [J].

Apostolakis, Stavros ;

Lane, Deirdre A. ;

Buller, Harry ;

Lip, Gregory Y. H. .

THROMBOSIS AND HAEMOSTASIS, 2013, 110 (05) :1074-1079

[6] Assessing Bleeding Risk in Atrial Fibrillation Patients: Comparing a Bleeding Risk Score Based Only on Modifiable Bleeding Risk Factors against the HAS-BLED Score. The AMADEUS Trial [J].

Asuncion Esteve-Pastor, Maria ;

Miguel Rivera-Caravaca, Jose ;

Shantsila, Alena ;

Roldan, Vanessa ;

Lip, Gregory Y. H. ;

Marin, Francisco .

THROMBOSIS AND HAEMOSTASIS, 2017, 117 (12) :2261-2266

[7] Long-term bleeding risk prediction in 'real world' patients with atrial fibrillation: Comparison of the HAS-BLED and ABC-Bleeding risk scores The Murcia Atrial Fibrillation Project [J].

Asuncion Esteve-Pastort, Maria ;

Rivera-Caravaca, Jose Miguel ;

Roldan, Vanessa ;

Vicente, Vicente ;

Valdes, Mariano ;

Marin, Francisco ;

Lip, Gregory Y. H. .

THROMBOSIS AND HAEMOSTASIS, 2017, 117 (10) :1848-1858

[8] Aspirin [J].

Awtry, EH ;

Loscalzo, J .

CIRCULATION, 2000, 101 (10) :1206-1218

[9] Ticagrelor with aspirin or alone in high-risk patients after coronary intervention: Rationale and design of the TWILIGHT study [J].

Baber, Usman ;

Dangas, George ;

Cohen, David J. ;

Gibson, C. Michael ;

Mehta, Shamir R. ;

Angiolillo, Dominick J. ;

Pocock, Stuart J. ;

Krucoff, Mitchell W. ;

Kastrati, Adnan ;

Ohman, E. Magnus ;

Steg, Philippe Gabriel ;

Badimon, Juan ;

Zafar, M. Urooj ;

Chandrasekhar, Jaya ;

Sartori, Samantha ;

Aquino, Melissa ;

Mehran, Roxana .

AMERICAN HEART JOURNAL, 2016, 182 :125-134

[10] Safety of coronary angiography and percutaneous coronary intervention via the radial versus femoral route in patients on uninterrupted oral anticoagulation with warfarin [J].

Baker, Nevin C. ;

O'Connell, Erik W. ;

Htun, Wah Wah ;

Sun, Haiyan ;

Green, Sandy M. ;

Skelding, Kimberly A. ;

Blankenship, James C. ;

Scott, Thomas D. ;

Berger, Peter B. .

AMERICAN HEART JOURNAL, 2014, 168 (04) :537-544

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