Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

被引：560

作者：

Perrin, Richard J. ^{[2
,3
,4
]}

Fagan, Anne M. ^{[1
,3
,4
]}

Holtzman, David M. ^{[1
,3
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Alzheimers Dis Res Ctr, St Louis, MO 63110 USA

来源：

NATURE | 2009年 / 461卷 / 7266期

基金：

美国国家卫生研究院;

关键词：

MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID A-BETA(42); AMYLOID-BETA; LIPID-PEROXIDATION; IN-VIVO; CSF BIOMARKERS; TAU PROTEINS; HUMAN BRAIN; PLASMA; PREDICTION;

D O I：

10.1038/nature08538

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Alzheimer's disease affects millions of people around the world. Currently, there are no treatments that prevent or slow the disease. Like other neurodegenerative diseases, Alzheimer's disease is characterized by protein misfolding in the brain. This process and the associated brain damage begin years before the substantial neurodegeneration that accompanies dementia. Studies using new neuroimaging techniques and fluid biomarkers suggest that Alzheimer's disease pathology can be detected preclinically. These advances should allow the design of new clinical trials and early mechanism-based therapeutic intervention.

引用

页码：916 / 922

页数：7

共 82 条

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Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease [J].