Neoral use in the renal transplant recipient

被引：16

作者：

Belitsky, P ^{[1
]}

机构：

[1] QEII Hlth Sci Ctr, Ctr Multiorgan Transplant, Halifax, NS, Canada

来源：

TRANSPLANTATION PROCEEDINGS | 2000年 / 32卷 / 3A期

关键词：

D O I：

10.1016/S0041-1345(00)00860-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review and critical analysis of current trends of immunosuppression management in renal transplantation provides evidence in support of the continued role of Neoral as an indispensable part of immunosuppressive protocols: CyA formulation influences clinical outcomes, particularly with respect to acute rejection, as confirmed by several multicenter studies. The CyA microemulsion formulation reduces pharmacokinetic variability and its consequent impact on outcomes over the long term. An advanced TDM strategy can improve the effectiveness and safety of immunosuppression in both de novo and maintenance renal transplant patients. There are potential risks resulting from CyA withdrawal strategies. Neoral is an indispensable part of combination protocols in renal transplantation.

引用

页码：10S / 19S

页数：10

共 55 条

[1] Comparison of efficacy, safety, and tolerability of neoral vs sandimmun in de novo renal transplant patients over 24 months' treatment [J].

Abendroth, D ;

Buchholz, B ;

Land, W ;

May, G ;

Wiesel, M ;

Farber, L ;

Korn, A ;

Maibucher, A .

TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) :275-276

[2]

Amante AJ, 1996, TRANSPLANT P, V28, P2162

[3]

BACKMAN L, 1998, 17 WORLD C TRANSPL S

[4] The pharmacokinetics of a microemulsion formulation of cyclosporine in primary renal allograft recipients [J].

Barone, G ;

Chang, CT ;

Choc, MG ;

Klein, JB ;

Marsh, CL ;

Meligeni, JA ;

Min, DI ;

Pescovitz, MD ;

Pollak, R ;

Pruett, TL ;

Stinson, JB ;

Thompson, JS ;

Vasquez, E ;

Waid, T ;

Wombolt, DG ;

Wong, RL .

TRANSPLANTATION, 1996, 61 (06) :875-880

[5]

BATIUK TD, 1995, 14 ANN M AM SOC TRAN

[6] Influence of drug formulation on utilization and outcomes: Neoral and monitoring by sparse sample area under the curve [J].

Belitsky, P ;

Mahalati, K ;

West, K ;

Sketris, I .

TRANSPLANTATION PROCEEDINGS, 1999, 31 (03) :1667-1668

[7]

BOUBENIDER S, 1998, 17 WORLD C TRANSPL S

[8]

CHEWWONG A, 1998, 17 WORLD C TRANSPL S

[9] Low exposure to cyclosporine is a risk factor for the occurrence of chronic rejection after kidney transplantation [J].

Citterio, F ;

Torricelli, P ;

Serino, F ;

Foco, M ;

Pozzetto, U ;

Fioravanti, P ;

Castagneto, M .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (05) :1688-1690

[10] Safety and tolerability of cyclosporine and cyclosporine microemulsion during 18 months of follow-up in stable renal transplant recipients - A report of the Canadian Neoral Renal Study Group [J].

Cole, E ;

Keown, P ;

Landsberg, D ;

Halloran, P ;

Shoker, A ;

Rush, D ;

Jeffrey, J ;

Russell, D ;

Stiller, C ;

Muirhead, N ;

Paul, L ;

Zaltzman, J ;

Loertscher, R ;

Daloze, P ;

Dandavino, R ;

Boucher, A ;

Handa, P ;

Lawen, J ;

Belitsky, P ;

Parfrey, P ;

Tan, A ;

Hendricks, L .

TRANSPLANTATION, 1998, 65 (04) :505-510

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