Modeling oxygen concentration in skeletal muscle

被引:9
作者
Salathe, EP
Gorman, AD
机构
[1] LEHIGH UNIV,INST BIOMED ENGN & MATH BIOL,BETHLEHEM,PA 18015
[2] LAFAYETTE COLL,DEPT MATH,EASTON,PA 18042
关键词
microcirculation; capillary; physiological transport; diffusion;
D O I
10.1016/S0895-7177(97)00147-7
中图分类号
TP39 [计算机的应用];
学科分类号
081203 [计算机应用技术]; 0835 [软件工程];
摘要
A new approach to modeling oxygen transport in skeletal muscle is presented that has the potential to include the interactions of a large number of capillaries. Oxygen concentration in tissue does not differ significantly from that in nearby capillaries, but the concentration in a capillary can be found only through a consideration of the interaction with other capillaries and the surrounding tissue. We therefore begin with an analysis of the oxygen concentration in the tissue surrounding a single capillary. By matching the concentration in adjacent tissue regions, we determine the interaction among capillaries. From this, two universal constants emerge that permit the capillary concentrations to be determined rather easily, without further consideration of the complex solution obtained for the tissue.
引用
收藏
页码:91 / 102
页数:12
相关论文
共 19 条
[1]
LOCAL OXYGEN GRADIENTS NEAR ISOLATED-MITOCHONDRIA [J].
CLARK, A ;
CLARK, PAA .
BIOPHYSICAL JOURNAL, 1985, 48 (06) :931-938
[2]
HOW LARGE IS THE DROP IN PO-2 BETWEEN CYTOSOL AND MITOCHONDRION [J].
CLARK, A ;
CLARK, PAA ;
CONNETT, RJ ;
GAYESKI, TEJ ;
HONIG, CR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (06) :C583-C587
[3]
CAPILLARY STRUCTURES AND O2 SUPPLY TO TISSUE - ANALYSIS WITH A DIGITAL DIFFUSION-MODEL AS APPLIED TO SKELETAL-MUSCLE [J].
GRUNEWALD, WA ;
SOWA, W .
REVIEWS OF PHYSIOLOGY BIOCHEMISTRY AND PHARMACOLOGY, 1977, 77 :149-209
[5]
CALCULATION OF OXYGEN PRESSURES IN TISSUE WITH ANISOTROPIC CAPILLARY ORIENTATION .1. 2-DIMENSIONAL ANALYTICAL SOLUTION FOR ARBITRARY CAPILLARY CHARACTERISTICS [J].
HOOFD, L .
MATHEMATICAL BIOSCIENCES, 1995, 129 (01) :1-23
[6]
CALCULATION OF OXYGEN PRESSURES IN TISSUE WITH ANISOTROPIC CAPILLARY ORIENTATION .2. COUPLING OF 2-DIMENSIONAL PLANES [J].
HOOFD, L .
MATHEMATICAL BIOSCIENCES, 1995, 129 (01) :25-39
[7]
AN ANALYSIS OF FACTORS AFFECTING TISSUE OXYGEN TENSION [J].
HUDSON, JA ;
CATER, DB .
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 161 (983) :247-+
[8]
The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue [J].
Krogh, A .
JOURNAL OF PHYSIOLOGY-LONDON, 1919, 52 (06) :409-415
[9]
INFLUENCE OF SPACE-DISTRIBUTED PARAMETERS ON CALCULATION OF SUBSTRATE AND GAS-EXCHANGE IN MICROVASCULAR UNITS [J].
METZGER, H .
MATHEMATICAL BIOSCIENCES, 1976, 30 (1-2) :31-45
[10]
PITTMAN RN, 1978, MICROVASCULAR PERFUS, P60