Orthotopic liver transplant patients require less postoperative morphine than do patients undergoing hepatic resection

Study Objective: To compare Postoperative morphine use, analgesic efficacy, and side effect profiles in patients following orthotopic liver transplantation (OLTx) and liver resection (LR). Design: Retrospective study. Setting: Liver transplant and liver resection surgery at a university hospital. Patients: 25 ASA physical status I, II, III, and IV patients undergoing OLTx or liver resection. Measurements and Main Results: Morphine use was significantly decreased in the OLTx patients at 6,12, 24, 48, and 72 hours following commencement of patient-controlled analgesia. After commencement of patient-controlled analgesia, pain scores were significantly reduced in the OLTx group compared with those in the liver resection group at 6 and 12 hours. Conclusions: Orthotopic liver transplant patients experienced less pain and used less morphine postoperatively than did liver resection patients. (C) 2002 by Elsevier Science Inc.