The molecular characteristics of colorectal cancer: Implications for diagnosis and therapy

被引：226

作者：

Ha Thi Nguyen ^{[1
]}

Hong-Quan Duong ^{[2
]}

机构：

[1] Duy Tan Univ, Inst Res & Dev, Ctr Mol Biol, 03 Quang Trung, Danang 550000, Vietnam

[2] Vinmec Res Inst Stem Cell & Gene Technol, Dept Canc Res, 458 Minh Khai, Hanoi 100000, Vietnam

来源：

ONCOLOGY LETTERS | 2018年 / 16卷 / 01期

关键词：

colorectal cancer; chromosomal instability; microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy; ISLAND METHYLATOR PHENOTYPE; DEFECTIVE MISMATCH REPAIR; POPULATION-BASED SAMPLE; PLURIPOTENT STEM-CELLS; MICROSATELLITE-INSTABILITY; COLON-CANCER; TUMOR-SUPPRESSOR; KRAS MUTATIONS; K-RAS; CHROMOSOMAL INSTABILITY;

D O I：

10.3892/ol.2018.8679

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Colorectal cancer (CRC) results from the progressive accumulation of multiple genetic and epigenetic aberrations within cells. The progression from colorectal adenoma to carcinoma is caused by three major pathways: Microsatellite instability, chromosomal instability and CpG island methylator phenotype. A growing body of scientific evidences suggests that CRC is a heterogeneous disease, and genetic characteristics of the tumors determine their prognostic outcome and response to targeted therapies. Early diagnosis and effective targeted therapies based on a current knowledge of the molecular characteristics of CRC are essential to the successful treatment of CRC. Therefore, the present review summarized the current understanding of the molecular characteristics of CRC, and discussed its implications for diagnosis and targeted therapy.

引用

页码：9 / 18

页数：10

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