In vitro anti-tyrosinase activity of 5-(Hydroxymethyl)-2-furfural isolated from Dictyophora indusiata

被引：92

作者：

Sharma, VK

Choi, J

Sharma, N

Choi, M

Seo, SY ^{[1
]}

机构：

[1] Kongju Natl Univ, Appl Biotechnol Lab, Dept Biol, Kong Ju 314701, South Korea

[2] Sunmoon Univ, Dept Appl Biol Sci, Chunan, South Korea

[3] Korean Collect Herbal Extract Inc, Kong Ju, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 10期

关键词：

Dictyophora indusiata; HMF and related analogues; tyrosinase inhibitor; noncompetitive inhibition;

D O I：

10.1002/ptr.1428

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds. Copyright (C) 2004 John Wiley Sons, Ltd.

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页码：841 / 844

页数：4

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