Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells

被引：573

作者：

Chen, Alex M. ^{[2
]}

Zhang, Min ^{[1
]}

Wei, Dongguang ^{[3
]}

Stueber, Dirk ^{[4
]}

Taratula, Oleh ^{[2
]}

Minko, Tamara ^{[1
]}

He, Huixin ^{[2
]}

机构：

[1] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Chem, Newark, NJ 07102 USA

[3] Carl Zeiss SMT Inc, Peabody, MA 01960 USA

[4] Merck & Co Inc, Pharmaceut Res, Rahway, NJ 07065 USA

来源：

SMALL | 2009年 / 5卷 / 23期

关键词：

apoptosis; Co-delivery; gene expression; nanotechnology; simultaneous delivery of drug and siRNA; ANTIAPOPTOTIC CELLULAR DEFENSE; OVARIAN-CARCINOMA; COPOLYMER; CYTOTOXICITY; ADRIAMYCIN; SYSTEM; DNA; ANTHRACYCLINES; INTERFERENCE; LOCALIZATION;

D O I：

10.1002/smll.200900621

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy of chemotherapy by conquering the nonpump resistance and possibly bypassing the efflux pump resistance (see image). © 2009 WILEY-VCH Verlag GmbH & Co. KGaA.

引用

页码：2673 / 2677

页数：5

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