Importing Mitochondrial Proteins: Machineries and Mechanisms

被引：1227

作者：

Chacinska, Agnieszka ^{[1
,2
]}

Koehler, Carla M. ^{[3
]}

Milenkovic, Dusanka ^{[1
,2
]}

Lithgow, Trevor ^{[4
]}

Pfanner, Nikolaus ^{[1
,2
]}

机构：

[1] Univ Freiburg, ZBMZ, Inst Biochem & Mol Biol, D-79104 Freiburg, Germany

[2] Univ Freiburg, Ctr Biol Signalling Studies, D-79104 Freiburg, Germany

[3] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

CELL | 2009年 / 138卷 / 04期

关键词：

DISULFIDE RELAY SYSTEM; OUTER-MEMBRANE BIOGENESIS; TWIN-PORE TRANSLOCASE; BETA-BARREL PROTEINS; SPACE RECEPTOR MIA40; M-AAA PROTEASE; INTERMEMBRANE SPACE; INNER MEMBRANE; PRESEQUENCE TRANSLOCASE; PREPROTEIN TRANSLOCASE;

D O I：

10.1016/j.cell.2009.08.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.

引用

页码：628 / 644

页数：17

共 130 条

[1]

Signal-anchored proteins follow a unique insertion pathway into the outer membrane of mitochondria [J].

Ahting, U ;

Waizenegger, T ;

Neupert, W ;

Rapaport, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) :48-53

[2]

Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria [J].

Ahting, U ;

Thieffry, M ;

Engelhardt, H ;

Hegerl, R ;

Neupert, W ;

Nussberger, S .

JOURNAL OF CELL BIOLOGY, 2001, 153 (06) :1151-1160

[3]

Fluorescence mapping of mitochondrial TM23 complex reveals a water-facing, substrate-interacting helix surface [J].

Alder, Nathan N. ;

Jensen, Robert E. ;

Johnson, Arthur E. .

CELL, 2008, 134 (03) :439-450

[4]

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria [J].

Banci, Lucia ;

Bertini, Ivano ;

Cefaro, Chiara ;

Ciofi-Baffoni, Simone ;

Gallo, Angelo ;

Martinelli, Manuele ;

Sideris, Dionisia P. ;

Katrakili, Nitsa ;

Tokatlidis, Kostas .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (02) :198-206

[5]

Biogenesis of the mitochondrial TOM complex - Mim1 promotes insertion and assembly of signal-anchored receptors [J].

Becker, Thomas ;

Pfannschmidt, Sylvia ;

Guiard, Bernard ;

Stojanovski, Diana ;

Milenkovic, Dusanka ;

Kutik, Stephan ;

Pfanner, Nikolaus ;

Meisinger, Chris ;

Wiedemann, Nils .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (01) :120-127

[6]

Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae [J].

Beilharz, T ;

Egan, B ;

Silver, PA ;

Hofmann, K ;

Lithgow, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8219-8223

[7]

The disulfide relay system of mitochondria is connected to the respiratory chain [J].

Bihlmaier, Karl ;

Mesecke, Nikola ;

Terziyska, Nadia ;

Bien, Melanie ;

Hell, Kai ;

Herrmann, Johannes M. .

JOURNAL OF CELL BIOLOGY, 2007, 179 (03) :389-395

[8]

A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to cytoskeleton-based segregation machinery [J].

Boldogh, IR ;

Nowakowski, DW ;

Yang, HC ;

Chung, HS ;

Karmon, S ;

Royes, P ;

Pon, LA .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (11) :4618-4627

[9]

The carboxyl-terminal third of the dicarboxylate carrier is crucial for productive association with the inner membrane twin-pore translocase [J].

Brandner, K ;

Rehling, P ;

Truscott, KN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (07) :6215-6221

[10]

Mitochondrial presequence translocase: Switching between TOM tethering and motor recruitment involves Tim21 and Tim17 [J].

Chacinska, A ;

Lind, M ;

Frazier, AE ;

Dudek, J ;

Meisinger, C ;

Geissler, A ;

Sickmann, A ;

Meyer, HE ;

Truscott, KN ;

Guiard, B ;

Pfanner, N ;

Rehling, P .

CELL, 2005, 120 (06) :817-829

← 1 2 3 4 5 6 7 8 9 10 →