Tumor-derived exosomes:: a new source of tumor rejection antigens

被引：174

作者：

André, F

Scharz, NEC

Chaput, N

Flament, C

Raposo, G

Amigorena, S

Angevin, E

Zitvogel, L

机构：

[1] Inst Gustave Roussy, Unite Immunol, Immunol Unit, F-94805 Villejuif, France

[2] Inst Curie, Paris, France

来源：

VACCINE | 2002年 / 20卷

关键词：

tumor-derived exosomes; tumor rejection antigens; cancer vaccines;

D O I：

10.1016/S0264-410X(02)00384-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Exosomes are small vesicles released by a broad array of hematopoietic cells. Previous studies showed that exosomes released by antigen loaded dendritic cells induce immune-mediated anti-tumor response in mice. Here, we will describe the biochemical properties of tumor-derived exosomes and, their pre-clinical activity as cancer vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：A28 / A31

页数：4

相关论文

共 24 条

[1]

Malignant effusions and immunogenic tumour-derived exosomes [J].

Andre, F ;

Schartz, NEC ;

Movassagh, M ;

Flament, C ;

Pautier, P ;

Morice, P ;

Pomel, C ;

Lhomme, C ;

Escudier, B ;

Le Chevalier, T ;

Tursz, T ;

Amigorena, S ;

Raposo, G ;

Angevin, E ;

Zitvogel, L .

LANCET, 2002, 360 (9329) :295-305

[2]

ANDRE F, UNPUB DENDRITIC CELL

[3]

Banchereau J, 2001, CANCER RES, V61, P6451

[4]

CHRISTIAN D, 2002, P AN M AM SOC CLIN, pA717

[5]

Identification of a factor that links apoptotic cells to phagocytes [J].

Hanayama, R ;

Tanaka, M ;

Miwa, K ;

Shinohara, A ;

Iwamatsu, A ;

Nagata, S .

NATURE, 2002, 417 (6885) :182-187

[6]

Activated platelets release two types of membrane vesicles:: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules [J].

Heijnen, HFG ;

Schiel, AE ;

Fijnheer, R ;

Geuze, HJ ;

Sixma, JJ .

BLOOD, 1999, 94 (11) :3791-3799

[7]

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors [J].

Heiser, A ;

Coleman, D ;

Dannull, J ;

Yancey, D ;

Maurice, MA ;

Lallas, CD ;

Dahm, P ;

Niedzwiecki, D ;

Gilboa, E ;

Vieweg, J .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (03) :409-417

[8]

A Toll-like receptor recognizes bacterial DNA [J].

Hemmi, H ;

Takeuchi, O ;

Kawai, T ;

Kaisho, T ;

Sato, S ;

Sanjo, H ;

Matsumoto, M ;

Hoshino, K ;

Wagner, H ;

Takeda, K ;

Akira, S .

NATURE, 2000, 408 (6813) :740-745

[9]

Role of antigen-presenting cells in long-term antitumor response based on tumor-derived apoptotic body vaccination [J].

Henry, F ;

Bretaudeau, L ;

Hequet, A ;

Barbieux, I ;

Lieubeau, B ;

Meflah, K ;

Grégoire, M .

PATHOBIOLOGY, 1999, 67 (5-6) :306-310

[10]

ADJUVANT ACTIVE SPECIFIC IMMUNOTHERAPY FOR HUMAN COLORECTAL-CANCER - 6.5-YEAR MEDIAN FOLLOW-UP OF A PHASE-III PROSPECTIVELY RANDOMIZED TRIAL [J].

HOOVER, HC ;

BRANDHORST, JS ;

PETERS, LC ;

SURDYKE, MG ;

TAKESHITA, Y ;

MADARIAGA, J ;

MUENZ, LR ;

HANNA, MG .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (03) :390-399