High Antibody Levels to P. gingivalis in Cardiovascular Disease

被引：26

作者：

Bohnstedt, S. ^{[1
]}

Cullinan, M. P. ^{[2
,3
]}

Ford, P. J. ^{[1
]}

Palmer, J. E. ^{[2
]}

Leishman, S. J. ^{[1
,2
]}

Westerman, B. ^{[2
]}

Marshall, R. I. ^{[1
]}

West, M. J. ^{[2
]}

Seymour, G. J. ^{[2
,3
]}

机构：

[1] Univ Queensland, Sch Dent, Brisbane, Qld 4000, Australia

[2] Univ Queensland, Sch Med, Brisbane, Qld 4000, Australia

[3] Univ Otago, Dept Oral Sci, Dunedin 9054, New Zealand

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 09期

基金：

英国医学研究理事会;

关键词：

periodontal disease; cardiovascular disease; serum antibodies; Porphyromonas gingivalis; strain variation; CORONARY-HEART-DISEASE; PORPHYROMONAS-GINGIVALIS; PERIODONTAL-DISEASE; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; ATHEROSCLEROSIS; INFECTION; RISK; HEAT-SHOCK-PROTEIN-60; PREVALENCE; PATHOGENS;

D O I：

10.1177/0022034510370817

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Recent evidence suggests that strain variation in the serum IgG response to Porphyromonas gingivalis occurs in periodontal disease and cardiovascular disease (CVD). This study aimed to test the hypothesis that different P. gingivalis strains would elicit different levels of IgG, depending on a patient's cardiovascular (CV) and periodontal health. For CVD patients, serum antibody levels increased significantly with increasing numbers of deep pockets for all strains of P. gingivalis, except W50 (p < 0.001). We used a two-way analysis of variance to examine differences in antibody responses across several CV and periodontal groups simultaneously. There was a significant interaction effect (p < 0.05) between periodontal status and CV status for antibody levels to ATCC33277, UQD605, and Su63. This study shows variation in strain type with respect to serum IgG response in several CV and periodontal categories, providing further support for the role of the immune response to P. gingivalis in the relationship between periodontal disease and CVD.

引用

页码：938 / 942

页数：5

共 33 条

[1]

Severity of periodontal disease correlates to inflammatory systemic status and independently predicts the presence and angiographic extent of stable coronary artery disease [J].

Amabile, N. ;

Susini, G. ;

Pettenati-Soubayroux, I. ;

Bonello, L. ;

Gil, J. -M. ;

Arques, S. ;

Bonfil, J. J. ;

Paganelli, F. .

JOURNAL OF INTERNAL MEDICINE, 2008, 263 (06) :644-652

[2]

Prevalence of specific genotypes of Porphyromonas gingivalis fimA and periodontal health status [J].

Amano, A ;

Kuboniwa, M ;

Nakagawa, I ;

Akiyama, S ;

Morisaki, I ;

Hamada, S .

JOURNAL OF DENTAL RESEARCH, 2000, 79 (09) :1664-1668

[3]

Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis [J].

Amano, A ;

Nakagawa, I ;

Okahashil, N ;

Hamada, N .

JOURNAL OF PERIODONTAL RESEARCH, 2004, 39 (02) :136-142

[4]

[Anonymous], 1996, Ann Periodontol, V1, P926

[5]

The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis [J].

Bahekar, Amol Ashok ;

Singh, Sarabjeet ;

Saha, Sandeep ;

Molnar, Janos ;

Arora, Rohit .

AMERICAN HEART JOURNAL, 2007, 154 (05) :830-837

[6]

Periodontal disease and cardiovascular disease [J].

Beck, J ;

Garcia, R ;

Heiss, G ;

Vokonas, PS ;

Offenbacher, S .

JOURNAL OF PERIODONTOLOGY, 1996, 67 (10) :1123-1137

[7]

Acquisition and loss of Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Prevotella intermedia over a 5-year period:: effect of a triclosan/copolymer dentifrice [J].

Cullinan, MP ;

Hamlet, SM ;

Westerman, B ;

Palmer, JE ;

Faddy, MJ ;

Seymour, GJ .

JOURNAL OF CLINICAL PERIODONTOLOGY, 2003, 30 (06) :532-541

[8]

DENTAL DISEASE AND RISK OF CORONARY HEART-DISEASE AND MORTALITY [J].

DESTEFANO, F ;

ANDA, RF ;

KAHN, HS ;

WILLIAMSON, DF ;

RUSSELL, CM .

BRITISH MEDICAL JOURNAL, 1993, 306 (6879) :688-691

[9]

Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis [J].

Dorn, BR ;

Burks, JN ;

Seifert, KN ;

Progulske-Fox, A .

FEMS MICROBIOLOGY LETTERS, 2000, 187 (02) :139-144

[10]

Infection and atherosclerosis - Emerging mechanistic paradigms [J].

Epstein, SE ;

Zhou, YF ;

Zhu, JH .

CIRCULATION, 1999, 100 (04) :E20-E28

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