RACK1, a versatile hub in cancer

被引：155

作者：

Li, J-J ^{[1
]}

Xie, D. ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Ctr Canc Res, Shanghai 200031, Peoples R China

来源：

ONCOGENE | 2015年 / 34卷 / 15期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

PROTEIN-KINASE-C; RECEPTOR-INTERACTING PROTEIN; HEPATOCELLULAR-CARCINOMA; TYROSINE-PHOSPHATASE; SCAFFOLD PROTEIN; BINDING-PROTEIN; DOWN-REGULATION; CELL-MIGRATION; BETA-SUBUNIT; INTERFERON RECEPTOR;

D O I：

10.1038/onc.2014.127

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

RACK1 is a highly conserved intracellular adaptor protein with significant homology to G beta and was originally identified as the anchoring protein for activated protein kinase C. In the past 20 years, the number of binding partners and validated cellular functions for RACK1 has increased, which facilitates clarification of its involvement in different biological events. In this review, we will focus on its role in cancer, summarizing its aberrant expression, pro- or anti-oncogenic effects and the underlying mechanisms in various cancers.

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页码：1890 / 1898

页数：9

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