Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

被引：113

作者：

Ehsanian, Reza ^{[1
,2
,3
]}

Van Waes, Carter ^{[1
]}

Feller, Stephan M. ^{[3
]}

机构：

[1] Natl Inst Deafness & Other Commun Disorders, Tumor Biol Sect, Head & Neck Surg Branch, NIH, Bethesda, MD 20892 USA

[2] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[3] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, Dept Mol Oncol,Cell Signalling Grp, Oxford OX3 9DS, England

来源：

CELL COMMUNICATION AND SIGNALING | 2011年 / 9卷

关键词：

NF-KAPPA-B; SQUAMOUS-CELL CARCINOMA; PROSTAGLANDIN-E SYNTHASE; ARACHIDONIC-ACID RELEASE; IRRADIATED HUMAN FIBROBLASTS; MALIGNANT PLEURAL EFFUSIONS; MULTIDRUG-RESISTANCE; PHOSPHOLIPASE A(2); TOPOISOMERASE-II; IN-VITRO;

D O I：

10.1186/1478-811X-9-13

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-kappa B, p53, and AKT pathways are summarized.

引用

页数：18

共 283 条

[1] STUDIES ON THE MECHANISM OF ALTERATION BY PROPRANOLOL AND MEPACRINE OF THE METABOLISM OF PHOSPHOINOSITIDES AND OTHER GLYCEROLIPIDS IN THE RABBIT IRIS MUSCLE [J].