Alternatives to Lung Transplantation: Treatment of Pulmonary Arterial Hypertension

被引：12

作者：

Corris, Paul A. ^{[1
,2
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

[2] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England

来源：

CLINICS IN CHEST MEDICINE | 2011年 / 32卷 / 02期

关键词：

Pulmonary arterial hypertension; Chronic thromboembolic pulmonary hypertension; Lung transplantation; Pulmonary endarterectomy; Atrial septostomy; CONTINUOUS INTRAVENOUS EPOPROSTENOL; BRAIN NATRIURETIC PEPTIDE; LONG-TERM TREATMENT; ATRIAL SEPTOSTOMY; DOUBLE-BLIND; PROSTACYCLIN THERAPY; INHALED ILOPROST; BOSENTAN THERAPY; SUBCUTANEOUS TREPROSTINIL; ANTAGONIST BOSENTAN;

D O I：

10.1016/j.ccm.2011.02.015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The development of targeted therapies for pulmonary arterial hypertension currently based on prostaglandin, nitric oxide, and endothelin pathways has resulted in major advances in the treatment of patients with pulmonary arterial hypertension. This article reviews the current evidence that supports both the use of mono- and combination therapy. The article also considers the role of atrial septostomy in the treatment of pulmonary arterial hypertension, particularly as a bridge to transplantation. Finally, the article provides a review of the role and outcomes of pulmonary thromboendartertectomy for patients with chronic thromboennbolic pulmonary hypertension.

引用

页码：399 / +

页数：13

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