Toward future therapies in progressive supranuclear palsy

被引:9
作者
Burn, DJ
Warren, NM
机构
[1] Newcastle Gen Hosp, Reg Neurosci Ctr, Dept Neurol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England
[2] Univ Newcastle Upon Tyne, Inst Hlth & Aging, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词
progressive supranuclear palsy; Steele-Richardson-Olszewski syndrome; trophic factors; treatment;
D O I
10.1002/mds.20546
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is a stern therapeutic challenge for progressive supranuclear palsy (PSP) that has not yet been met. The lack of randomized, controlled trials and negative outcomes from the vast majority of studies make it impossible to set therapeutic standards, or to give clear recommendations. We review progress to date in this area and briefly consider future potential therapeutic strategies. (c) 2005 Movement Disorder Society.
引用
收藏
页码:S92 / S98
页数:7
相关论文
共 71 条
[1]
Performance on the dementia rating scale in Parkinson's disease with dementia and dementia with Lewy bodies: comparison with progressive supranuclear palsy and Alzheimer's disease [J].
Aarsland, D ;
Litvan, I ;
Salmon, D ;
Galasko, D ;
Wentzel-Larsen, T ;
Larsen, JP .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2003, 74 (09) :1215-1220
[2]
Agid Y., 1992, PROGRESSIVE SUPRANUC, P254
[3]
CEREBROSPINAL-FLUID ACETYLCHOLINESTERASE IN PROGRESSIVE SUPRANUCLEAR PALSY - REDUCED ACTIVITY RELATIVE TO NORMAL SUBJECTS AND LACK OF INHIBITION BY ORAL PHYSOSTIGMINE [J].
ATACK, JR ;
LITVAN, I ;
THAL, LJ ;
MAY, C ;
RAPOPORT, SI ;
CHASE, TN .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1991, 54 (09) :832-835
[4]
Limited usefulness of electroconvulsive therapy in progressive supranuclear palsy [J].
Barclay, CL ;
Duff, J ;
Sandor, P ;
Lang, AE .
NEUROLOGY, 1996, 46 (05) :1284-1286
[5]
Progressive supranuclear palsy diagnosis and confounding features: Report on 16 autopsied cases [J].
Birdi, S ;
Rajput, AH ;
Fenton, M ;
Donat, JR ;
Rozdilsky, B ;
Robinson, C ;
Macaulay, R ;
George, D .
MOVEMENT DISORDERS, 2002, 17 (06) :1255-1264
[6]
Does the enhancement of cholinergic neurotransmission influence brain glucose kinetics and clinical symptomatology in progressive supranuclear palsy? [J].
Blin, J ;
Mazetti, P ;
Mazoyer, B ;
Rivaud, S ;
BenAyed, S ;
Malapani, C ;
Pillon, B ;
Agid, Y .
BRAIN, 1995, 118 :1485-1495
[7]
Bonuccelli U, 1992, Funct Neurol, V7, P295
[8]
Progressive supranuclear palsy: where are we now? [J].
Burn, DJ ;
Lee, AJ .
LANCET NEUROLOGY, 2002, 1 (06) :359-369
[9]
Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study [J].
Caparros-Lefebvre, D ;
Elbaz, A .
LANCET, 1999, 354 (9175) :281-286
[10]
Zolpidem in progressive supranuclear palsy [J].
Daniele, A ;
Moro, E ;
Bentivoglio, AR .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (07) :543-544