Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

被引：73

作者：

Holbrook, Joanna D. ^{[1
,2
]}

Parker, Joel S. ^{[3
]}

Gallagher, Kathleen T. ^{[4
]}

Halsey, Wendy S. ^{[4
]}

Hughes, Ashley M. ^{[4
]}

Weigman, Victor J. ^{[3
]}

Lebowitz, Peter F. ^{[1
]}

Kumar, Rakesh ^{[1
]}

机构：

[1] Glaxosmithkline R&D, Oncol R&D, Canc Res, Collegeville, PA USA

[2] Natl Univ Singapore, Brenner Ctr Mol Med, Agcy Sci Technol & Res A STAR, Growth Dev & Metab Programme,SICS, Singapore 117609, Singapore

[3] Express Anal Inc, Durham, NC 27713 USA

[4] Glaxosmithkline R&D, MDR, Collegeville, PA USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2011年 / 9卷

关键词：

RECEPTOR TYROSINE KINASE; T-CELL LYMPHOMA; C-MET RECEPTOR; CANCER-CELLS; IN-VITRO; SIGNALING PATHWAYS; THERAPEUTIC TARGET; ANTITUMOR-ACTIVITY; MTOR INHIBITION; STOMACH-CANCER;

D O I：

10.1186/1479-5876-9-119

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Background: Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. Methods: Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers. Results: Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways. Conclusions: The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to similar to 22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.

引用

页数：13

共 113 条

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Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells [J].