Cardiac-induced physiologic noise in tissue is a direct observation of cardiac-induced fluctuations

Recent studies have shown that in certain cases, cardiac and respiratory rate fluctuations in BOLD-weighted MR1 time courses may be an artifact unique to rapid sampled acquisitions and may not be present in longer repetition-time acquisitions. The implication of this is that, in these cases, cardiac and respiratory rate fluctuations are not aliased into data that undersample these effects and do not affect the resulting time course measurements. In this study, we show that these cases are specific to regions of large cerebrospinal fluid content and are not generally true for gray matter regions of the brain. We demonstrate that in many brain regions of interest, these fluctuations are directly observed as BOLD fluctuations and thus will affect measurements that undersample these effects. (C) 2004 Elsevier Inc. All rights reserved.