Th2 cells support intrinsic anti-inflammatory properties of the brain

被引：39

作者：

Gimsa, U ^{[1
]}

Wolf, SA ^{[1
]}

Haas, D ^{[1
]}

Bechmann, I ^{[1
]}

Nitsch, R ^{[1
]}

机构：

[1] Humboldt Univ, Clin Charite, Inst Anat, Dept Cell & Neurobiol, D-10098 Berlin, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 119卷 / 01期

关键词：

brain slice cultures; costimulation; microglial activation; MBP; experimental autoimmune encephalomyelitis;

D O I：

10.1016/S0165-5728(01)00343-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In experimental autoimmune encephalomyelitis (EAE), Th1 cells are responsible for disease induction while Th2 cells can be protective. To address the mechanisms of this differential behavior, we utilized organotypic murine entorhinal-hippocampal slice cultures to analyze interactions between myelin basic protein-specific Th1 and Th2 cells with microglial cells. While both Th1 and Th2 cells induced CD40 expression, only Th1 cells induced intercellular adhesion molecule-1 (ICAM-1) expression on microglia. Moreover, Th2 cells prevented or even reversed Th1-induced ICAM-1 upregulation. Evidently, Th2 cells could diminish Th1-induced inflammatory reactions and actively support the resting state of microglia, which could be one mechanism of Th2-mediated remission of neuroinflammation during EAE. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：73 / 80

页数：8

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