The in vivo cytokine release profile following implantation

被引：16

作者：

Baldwin, L. ^{[1
]}

Hunt, J. A. ^{[1
]}

机构：

[1] Univ Liverpool, UKCTE, Sch Clin Sci UKCTE, Liverpool L69 3GA, Merseyside, England

来源：

CYTOKINE | 2008年 / 41卷 / 03期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

implantation; interleukin-1; TNF-alpha; interleukin-6; inflammation;

D O I：

10.1016/j.cyto.2007.11.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

There has been no comprehensive study that maps the production of the range of inflammatory cytokines following implantation of a material. There is an urgent requirement for specific data on the real time production of biological markers in order to study their effects in vitro and more accurately predict the in vivo response. This study determined the production of IL-1 beta, IL-2, IL-4, IL-6 IL-10, IFN gamma and TNF-alpha in response to a synthetic material implanted in a rat soft tissue model for up to 90 days. IL-1 beta and TNF-alpha were elevated over the total experimental time course with values in the order of 500 pg/ml for IL-1 beta and 40 pg/ml for TNF-alpha. The cytokines IL-2, IL-4, IL-6 and IL-10 were also detected and their production reduced with increasing time. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：217 / 222

页数：6

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