Antithrombotic lipids from Semen Persicae

被引：117

作者：

Yang, Nian-Yun ^{[1
]}

Liu, Li ^{[1
]}

Tao, Wei-Wei ^{[1
]}

Duan, Jin-Ao ^{[1
]}

Liu, Xun-Hong ^{[2
]}

Huang, Su-Ping ^{[3
]}

机构：

[1] Nanjing Univ Tradit Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Tradit Chinese Med, Coll Pharm, Nanjing 210046, Jiangsu, Peoples R China

[3] Jinling Pharmaceut Co Ltd, Jinling Pharmaceut Factory, Nanjing 210009, Jiangsu, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2011年 / 25卷 / 17期

关键词：

Semen Persicae; Prunus persica; fatty acid; antithrombotic activity; ATHEROSCLEROSIS; ACID; PATHOGENESIS; TIME;

D O I：

10.1080/14786419.2011.568942

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Chemical investigation of Semen Persicae has led to the isolation of decane (1), triolein (2), nonacosanoic acid (3), oleic acid ethyl ester (4), palmitic acid (5), oleic acid (6) and 15,16-dihydroxy-9Z,12Z-octadecadienoic acid 2,3-dihydroxypropyl ester (7). Amongst these, compound 7 is a new lipid. Their structures were elucidated by chemical and extensive spectral analysis. Their anticoagulative activities were also evaluated in vitro, which showed that petroleum ether extract and compounds 5-6 could significantly prolong thrombin time while methanol extract could obviously inhibit platelet aggregation.

引用

页码：1650 / 1656

页数：7

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