An IL-1 family member requires caspase-1 processing and signals through the ST2 receptor

被引：192

作者：

Dinarello, CA ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA

来源：

IMMUNITY | 2005年 / 23卷 / 05期

关键词：

D O I：

10.1016/j.immuni.2005.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Activation of ST2, an orphan member of the IL-1 receptor family for 16 years, drives T helper type 2 (T(H)2) responses. The cytokine IL-33 is the specific ligand for ST2. IL-33 recapitulates much of the existing data that ST2 promotes T(H)2-type responses. The caspase-1 processing of precursor IL-33 provides a therapeutic target to control allergic diseases.

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收藏

页码：461 / 462

页数：2

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