Transition metals in organic synthesis, part 85.: A general approach to 1,6-dioxygenated carbazole alkaloids -: First total synthesis of clausine G, clausine I, and clausine Z

被引：37

作者：

Boerger, Carsten ^{[1
]}

Knoelker, Hans-Joachim ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany

来源：

SYNLETT | 2008年 / 11期

关键词：

alkaloids; antibiotics; catalysis; cyclizations; palladium;

D O I：

10.1055/s-2008-1077855

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using the palladium-catalyzed construction of the carbazole framework, a highly efficient route to 1,6-dioxygenated carbazole alkaloids has been developed and applied to the total synthesis of clausenine, 6-methoxymurrayanine, clausenol, clausine G, clausine I, and clausine Z. The three latter natural products have been synthesized for the first time.

引用

页码：1698 / 1702

页数：5

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