Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

被引：141

作者：

Allen, JD ^{[1
]}

Verhoeven, E ^{[1
]}

Domen, J ^{[1
]}

vanderValk, M ^{[1
]}

Berns, A ^{[1
]}

机构：

[1] NETHERLANDS CANC INST,DIV MOL GENET,NL-1066 CX AMSTERDAM,NETHERLANDS

来源：

ONCOGENE | 1997年 / 15卷 / 10期

关键词：

lymphomagenesis; leukemogenesis; transgenic mice; X-inactivation; oncogene; pim-2;

D O I：

10.1038/sj.onc.1201288

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence from proviral tagging experiments has suggested that pim-2 is similar in oncogenic behavior to its well characterized relative pim-1. While expression in tissues differs, both genes expressed in mitogenically stimulated hematopoietic cells and their transcription is induced in response to the same cytokines, Expression of a pim-2 transgene in lymphoid cells predisposed mice to T-cell lymphomas like those promoted by pim-1 transgenes, Moreover, strong collaboration with an E mu-myc transgene was manifested as pre-B cell leukemia in neonate bi-transgenic animals, Remarkably, this collaboration was attenuated but not prevented by X-inactivation of one of the transgenes. The addition of pim-2 to the fold increases the prominence of the pim proto-oncogene family in tumorigenesis.

引用

页码：1133 / 1141

页数：9

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