Dictyostelium development in the absence of cAMP

被引：87

作者：

Wang, B ^{[1
]}

Kuspa, A ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT BIOCHEM,HOUSTON,TX 77030

来源：

SCIENCE | 1997年 / 277卷 / 5323期

关键词：

D O I：

10.1126/science.277.5323.251

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adenosine 3',5'-monophosphate (cAMP) and cAMP-dependent protein kinase (PKA) are regulators of development in many organisms. Dictyostelium uses cAMP as an extracellular chemoattractant and as an intracellular signal for differentiation. Cells that are mutant in adenylyl cyclase do not develop. Moderate expression of the catalytic subunit of PKA in adenylyl cyclase-null cells led to near-normal development without detectable accumulation of cAMP. These results suggest that all intracellular cAMP signaling is effected through PKA and that signals other than extracellular cAMP coordinate morphogenesis in Dictyostelium.

引用

页码：251 / 254

页数：4

共 62 条

[1] A NEW CLASS OF RAPIDLY DEVELOPING MUTANTS IN DICTYOSTELIUM-DISCOIDEUM - IMPLICATIONS FOR CYCLIC-AMP METABOLISM AND CELL-DIFFERENTIATION [J].