共 23 条
Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis
被引:336
作者:

Tsuji, Takanori
论文数: 0 引用数: 0
h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Ibaragi, Soichiro
论文数: 0 引用数: 0
h-index: 0
机构:
Okayama Univ, Grad Sch, Dept Oral & Maxillofacial Surg, Okayama, Japan Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

Hu, Guo-fu
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA
[3] Okayama Univ, Grad Sch, Dept Oral & Maxillofacial Surg, Okayama, Japan
基金:
美国国家卫生研究院;
关键词:
TUMOR PROGRESSION;
INVASION;
INACTIVATION;
METHYLATION;
EXPRESSION;
INDUCTION;
DIVERSITY;
GROWTH;
EMT;
D O I:
10.1158/0008-5472.CAN-09-1618
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The role of epithelial-mesenchymal transition (EMT) in metastasis remains controversial. EMT has been postulated as an absolute requirement for tumor invasion and metastasis. Three different models including incomplete EMT, mesenchymal-epithelial transition (MET), and collective migration have been proposed for the role of EMT in cancer invasion and metastasis. However, skepticism remains about whether EMT truly occurs during cancer progression, and if it does, whether it plays an indispensible role in metastasis. Our recent findings suggest that EMT cells are responsible for degrading the surrounding matrix to enable invasion and intravasation of both EMT and non-EMT cells. Only non-EMT cells that have entered the blood stream are able to re-establish colonies in the secondary sites. Here, we discuss an alternative model for the role of EMT in cancer metastasis in which EMT and non-EMT cells cooperate to complete the entire process of spontaneous metastasis. [Cancer Res 2009;69(18):7135-9]
引用
收藏
页码:7135 / 7139
页数:5
相关论文
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