Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine

被引：39

作者：

León, A ^{[1
]}

Martinez, E ^{[1
]}

Mallolas, J ^{[1
]}

Laguno, M ^{[1
]}

Blanco, JL ^{[1
]}

Pumarola, T ^{[1
]}

Gatell, JM ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, Infect Dis Unit, Barcelona, Spain

来源：

AIDS | 2005年 / 19卷 / 02期

关键词：

D O I：

10.1097/00002030-200501280-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 50% rate of early virological failure associated with the selection of resistance mutations was seen in a group of 14 antiretroviral-naive adults who initiated highly active antiretroviral therapy with tenofovir and didanosine plus efavirenz or nevirapine. At month 6, the mutations detected were K65R, L74V, L100I, K103N/R/T, Y181C and G190E/Q/S. These results argue against the use of tenofovir plus didanosine in HIV-infected antiretroviral-naive adults even when the third drug is a non-nucleoside reverse transcriptase inhibitor.

引用

页码：213 / 215

页数：3

共 9 条

[1]

D'Aquila Richard T, 2003, Top HIV Med, V11, P92

[2] Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection [J].

Gulick, RM ;

Ribaudo, HJ ;

Shikuma, CM ;

Lustgarten, S ;

Squires, KE ;

Meyer, WA ;

Acosta, EP ;

Schackman, BR ;

Pilcher, CD ;

Murphy, RL ;

Maher, WE ;

Witt, MD ;

Reichman, RC ;

Snyder, S ;

Klingman, KL ;

Kuritzkes, DR .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (18) :1850-1861

[3]

JEMSEK J, 2004, 11 C RETR OPP INF SA

[4]

KAUL S, 2003, 4 INT WORKSH CLIN PH

[5] Pancreatic toxic effects associated with co-administration of didanosine and tenofovir in HIV-infected adults [J].

Martínez, E ;

Milinkovic, A ;

de Lazzari, E ;

Ravasi, G ;

Blanco, JL ;

Larrousse, M ;

Mallolas, J ;

García, F ;

Miró, JM ;

Gatell, JM .

LANCET, 2004, 364 (9428) :65-67

[6] Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load [J].

Negredo, E ;

Moltó, J ;

Burger, D ;

Viciana, P ;

Ribera, E ;

Paredes, R ;

Juan, M ;

Ruiz, L ;

Puig, J ;

Pruvost, A ;

Grassi, J ;

Masmitjà, E ;

Clotet, B .

AIDS, 2004, 18 (03) :459-463

[7]

PETROPOULOS CJ, 2003, 43 INT C ANT AG CHEM

[8]

PODZAMCZER D, 2004, 13 INT HIV DRUG RES

[9] Resistance issues with new nucleoside/nucleotide backbone options [J].

Wainberg, MA ;

Turner, D .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2004, 37 :S36-S43

← 1 →