Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology

被引：114

作者：

Brunner, T ^{[1
]}

Wasem, C ^{[1
]}

Torgler, R ^{[1
]}

Cima, I ^{[1
]}

Jakob, S ^{[1
]}

Corazza, N ^{[1
]}

机构：

[1] Univ Bern, Inst Pathol, Div Immunopathol, CH-3010 Bern, Switzerland

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 03期

关键词：

apoptosis; death receptors; disease; lymphocyte; transcription;

D O I：

10.1016/S1044-5323(03)00035-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Members of the tumor necrosis factor (TNF) superfamily are crucially involved in the regulation of T cell activation, homeostasis and cytotoxicity. In particular, Fas ligand (FasL), expressed by activated T lymphocytes, induces cell-mediated cytotoxicity and may also be responsible for apoptotic suicide. Tight regulation of this death-inducing ligand is a prerequisite for proper immune defense and homeostasis. In this review, we will discuss various aspects of FasL regulation in cell-mediated cytotoxicity, immune homeostasis and the inu-nunopathology of diseases. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：167 / 176

页数：10

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