Brain extracellular matrix

被引：374

作者：

Ruoslahti, E

机构：

[1] La Jolla Cancer Research Center, Burnham Institute, San Diego

来源：

GLYCOBIOLOGY | 1996年 / 6卷 / 05期

关键词：

extracellular matrix; lectican; versican; review;

D O I：

10.1093/glycob/6.5.489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extracellular matrix of the adult brain tissue has a unique composition. The striking feature of this matrix is the prominence of lecticans, proteoglycans that contain a lectin domain and a hyaluronic acid-binding domain. Hyaluronic acid and tenascin family adhesive/anti-adhesive proteins are also abundant. Matrix proteins common in other tissues are nearly absent in adult brain. The brain extracellular matrix appears to have trophic effects on neuronal cells and affect neurite outgrowth. The unique composition of this matrix may be responsible for the resistance of brain tissue toward invasion by tumors of non-neuronal origin.

引用

页码：489 / 492

页数：4

共 50 条

[1] EXTRACELLULAR-MATRIX OF CENTRAL-NERVOUS-SYSTEM WHITE MATTER - DEMONSTRATION OF AN HYALURONATE-PROTEIN COMPLEX [J].