Sly as a FOXO: New paths with forkhead signaling in the brain

被引：67

作者：

Maiese, Kenneth ^{[1
,2
,3
]}

Chong, Zhao Zhong ^{[1
]}

Shang, Yan Chen ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Neurol, Div Cell & Mol Cerebral Ischemia, Detroit, MI 48201 USA

[2] Wayne State Univ, Ctr Mol Med & Genet & Inst Environm Hlth Sci, Inst Environm Hlth Sci, Dept Neurol & Anat, Detroit, MI 48201 USA

[3] Wayne State Univ, Ctr Mol Med & Genet, Inst Environm Hlth Sci, Dept Cell Biol, Detroit, MI 48201 USA

来源：

CURRENT NEUROVASCULAR RESEARCH | 2007年 / 4卷 / 04期

关键词：

amyotrophic lateral sclerosis; diabetes; apoptosis; FOXO3a; FKHRL1; Akt; erythropoietin; neuromuscular disease; oxidative stress; psychiatric; systemic lupus erythematosus; stroke; stem cells;

D O I：

10.2174/156720207782446306

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus crythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.

引用

收藏

页码：295 / 302

页数：8

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