The inverted CD4:CD8 ratio is associated with gender-related changes in oxidative stress during aging

被引：39

作者：

Muller, Guilherme Cerutti ^{[1
,2
]}

Valle Gottlieb, Maria Gabriela ^{[3
]}

Correa, Bruna Luz ^{[1
]}

Gomes Filho, Irenio ^{[3
]}

Moresco, Rafael Noal ^{[4
]}

Bauer, Moises Evandro ^{[1
]}

机构：

[1] Pontif Catholic Univ Rio Grande do Sul, Inst Biomed Res, Lab Immunosenescence, Porto Alegre, RS, Brazil

[2] Univ Vale Rio dos Sinos UNISINOS, Hlth Sch, BR-93022000 Sao Leopoldo, RS, Brazil

[3] Pontificia Univ Catolica Rio Grande do Sul, Inst Gerontol & Geriatr, Porto Alegre, RS, Brazil

[4] Univ Fed Santa Maria, Hlth Sci Ctr, Dept Clin & Toxicol Anal, BR-97119900 Santa Maria, RS, Brazil

来源：

CELLULAR IMMUNOLOGY | 2015年 / 296卷 / 02期

关键词：

Immune risk profile; Cytomegalovirus; Oxidative stress; Inflammation; Antioxidant power; Immunosenescence; SWEDISH NONA IMMUNE; T-LYMPHOCYTE SUBPOPULATIONS; CYTOMEGALOVIRUS-SEROPOSITIVITY; PROTEIN PRODUCTS; RISK PHENOTYPE; CD4/CD8; RATIO; OLD-AGE; INFLAMMATION; MARKERS; DISEASE;

D O I：

10.1016/j.cellimm.2015.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Aging has been associated with increased generation of free radicals as well as immunosenescence. Previous studies have identified older individuals with inverted T CD4:CD8 cell ratio and increased immunity to cytomegalovirus (CMV). Here, we investigated markers of oxidative stress and antioxidant defences in older individuals with inverted CD4:CD8 T-cell ratio. Sixty-one subjects were identified with inverted CD4:CD8 ratio. Older individuals with a CD4:CD8 ratio <1 had increased levels of plasma advanced oxidation protein products (AOPP) and ferric reducing ability of plasma (FRAP), but reduced levels of thiobarbituric acid reactive substances (TBARS) as compared to subjects with normal CD4:CD8 ratio. The CMV IgG serology was negatively correlated with CD4:CD8 ratio. These markers were more evident among elderly men than women. Our data suggest a close relationship between chronic CMV infection and oxidative profile in older individuals in the midst of its influence on the peripheral T-cell subsets. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：149 / 154

页数：6

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