The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study

被引：176

作者：

Zhao, Jing ^{[1
]}

Xia, Weibo ^{[1
]}

Nie, Min ^{[1
]}

Zheng, Xin ^{[2
]}

Wang, Qiuping ^{[3
]}

Wang, Xiran ^{[4
]}

Wang, Wenbo ^{[5
]}

Ning, Zhiwei ^{[6
]}

Huang, Wei ^{[7
]}

Jiang, Yan ^{[1
]}

Li, Mei ^{[1
]}

Wang, Ou ^{[1
]}

Xing, Xiaoping ^{[1
]}

Sun, Yue ^{[1
]}

Luo, Lianmei ^{[1
]}

He, Shuli ^{[1
]}

Yu, Wei ^{[8
]}

Lin, Qiang ^{[8
]}

Pei, Yu ^{[9
]}

Zhang, Fan ^{[3
]}

Han, Youxia ^{[7
]}

Tong, Yanmin ^{[2
]}

Che, Ying ^{[5
]}

Shen, Ruixin ^{[10
]}

Hu, Yingying ^{[1
]}

Zhou, Xueying ^{[1
]}

Xu, Ling ^{[11
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Dept Endocrinol,Key Lab Endocrinol, Beijing 100730, Peoples R China

[2] China Rehabil Res Ctr, Dept Endocrinol, Beijing, Peoples R China

[3] Beijing Liangxiang Hosp, Dept Endocrinol, Beijing, Peoples R China

[4] Gen Hosp Second Artillery Force, Dept Cadre Unit, Beijing, Peoples R China

[5] Peking Univ, Shougang Hosp, Dept Endocrinol, Beijing 100871, Peoples R China

[6] Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Endocrinol, Beijing, Peoples R China

[7] Beijing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China

[8] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China

[9] Gen Hosp, Chinese Peoples Liberat Army, Dept Geriatr Endocrinol, Beijing, Peoples R China

[10] Capital Univ Med Sci, Beijing Chaoyang Hosp, Dept Orthoped, Beijing, Peoples R China

[11] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Obstet & Gynecol, Beijing 100730, Peoples R China

来源：

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2011年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Bone mineral density; C-terminal telopeptide of type I collagen; Fracture; N-aminoterminal propeptide of type I collagen; Vertebral fracture; 25-Hydroxyvitamin D; VITAMIN-D STATUS; MINERAL DENSITY; BIOCHEMICAL MARKERS; ELDERLY-WOMEN; D SUPPLEMENTATION; HIP FRACTURE; I COLLAGEN; METABOLISM; PREDICTION; TELOPEPTIDE;

D O I：

10.1097/gme.0b013e31821d7ff7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Objective: The aim of this study was to evaluate serum N-aminoterminal propeptide of type I collagen (P1NP), C-terminal telopeptide of type I collagen (beta-CTX), and vitamin D status in healthy Chinese postmenopausal women. The study was also designed to investigate their possible relationships with osteoporosis phenotypes. Methods: A community-based population of 1,724 postmenopausal women in Beijing was randomly selected. Serum bone turnover markers and 25-hydroxyvitamin D [25(OH) D] were tested by an automated Roche electro-chemiluminescence system. Dual-energy x-ray absorptiometry was used to measure bone mineral density (BMD). Results: The mean (SD) values of serum beta-CTX and P1NP were 0.439 (0.210) and 56.7 (27.9) ng/mL, respectively. The 25(OH) D level of postmenopausal women in Beijing was remarkably low (13.2 +/- 5.4 ng/mL). Serum beta-CTX and P1NP levels were negatively correlated with BMDs of lumbar spine, femoral neck, and total hip (all P < 0.01). The cubic regression model better fitted the relationships of BMD and bone turnover markers. Serum beta-CTX levels were significantly higher in women with sustained osteoporotic fracture or vertebral fracture (P = 0.006 and 0.012, respectively). No association between P1NP and fracture or vertebral fracture was detected. The same situation applied to 25(OH) D. 25(OH) D was negatively correlated with beta-CTX and P1NP (r = -0.073 and -0.088, P = 0.002 and <0.001, respectively). Conclusions: Serum beta-CTX and P1NP levels were negatively correlated with BMD. beta-CTX was significantly higher in postmenopausal women with sustained fracture or vertebral fracture. Vitamin D deficiency was highly prevalent in postmenopausal women in Beijing.

引用

页码：1237 / 1243

页数：7

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