Natural regulatory CD4 T cells expressing CD25

被引：13

作者：

Papiernik, M ^{[1
]}

Banz, A ^{[1
]}

机构：

[1] Inst Necker, Inserm U345, F-75730 Paris 15, France

来源：

MICROBES AND INFECTION | 2001年 / 3卷 / 11期

关键词：

CD4 regulatory T cells; interleukin-2 receptor alpha chain; superantigen; interleukin-10; inflammatory reaction; autoimmune diseases;

D O I：

10.1016/S1286-4579(01)01455-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In normal mice, a subpopulation of CD4 T cells constitutively express CD25. These cells behave as regulatory T cells in autoimmune and inflammatory reactions, in tolerance to superantigens, and in peripheral T-cell homeostasis. They are unable to produce interleukin (IL)-2, and are dependent on IL-2 for growth in vitro and in vivo. CD4 CD25(+) T cells spontaneously secrete IL-10, which is involved in some of their regulatory functions. They are resistant to apoptosis, but can be tolerized by anergy. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：937 / 945

页数：9

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