Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity

被引：25

作者：

Shin, Hyun-Woo ^{[1
]}

Han, Doo Hee ^{[1
,3
]}

Lim, Yune Sung ^{[1
]}

Kim, Hye Jung ^{[1
]}

Kim, Dong-Young ^{[1
]}

Lee, Chul Hee ^{[1
,2
]}

Min, Yang-Gi ^{[1
]}

Rhee, Chae-Seo ^{[1
,2
,3
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol, Seoul 110744, South Korea

[2] Seoul Natl Univ, Med Res Ctr, Sensory Organ Res Inst, Seoul 110744, South Korea

[3] Seoul Natl Univ, Med Res Ctr, Inst Allergy & Clin Immunol, Seoul 110744, South Korea

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2009年 / 141卷 / 04期

关键词：

MATRIX METALLOPROTEINASES; CHRONIC RHINOSINUSITIS; TISSUE INHIBITOR; RHINITIS; EXPRESSION; MUCOSA; CHALLENGE; DISEASE; TIMP-1; ASTHMA;

D O I：

10.1016/j.otohns.2009.07.011

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

OBJECTIVE: To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloprotemase (TIMP-1) in nasal polyposis. STUDY DESIGN: A case-control study. SETTING: A tertiary referral center. SUBJECTS AND METHODS: The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosm staining were also performed and those expression levels were compared. RESULTS: Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group. CONCLUSION: The presence of AR may enhance the expression of MAV-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis. (C) 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.

引用

页码：442 / 447

页数：6

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