Divalent cation transport and susceptibility to infectious and autoimmune disease:: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

被引：127

作者：

Blackwell, JM ^{[1
]}

Searle, S ^{[1
]}

Mohamed, H ^{[1
]}

White, JK ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Cambridge Inst Med Res, Addenbrookes Hosp, Cambridge CB2 2XY, England

来源：

IMMUNOLOGY LETTERS | 2003年 / 85卷 / 02期

基金：

英国惠康基金;

关键词：

Slc11a1; Nramp1; resistance to infection; autoimmune disease susceptibility;

D O I：

10.1016/S0165-2478(02)00231-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：197 / 203

页数：7

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