Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

被引：614

作者：

Carlton, Jane M.

Hirt, Robert P.

Silva, Joana C.

Delcher, Arthur L.

Schatz, Michael

Zhao, Qi

Wortman, Jennifer R.

Bidwell, Shelby L.

Alsmark, U. Cecilia M.

Besteiro, Sebastien

Sicheritz-Ponten, Thomas

Noel, Christophe J.

Dacks, Joel B.

Foster, Peter G.

Simillion, Cedric

Van de Peer, Yves

Miranda-Saavedra, Diego

Barton, Geoffrey J.

Westrop, Gareth D.

Mueller, Sylke

Dessi, Daniele

Fiori, Pier Luigi

Ren, Qinghu

Paulsen, Ian

Zhang, Hanbang

Bastida-Corcuera, Felix D.

Simoes-Barbosa, Augusto

Brown, Mark T.

Hayes, Richard D.

Mukherjee, Mandira

Okumura, Cheryl Y.

Schneider, Rachel

Smith, Alias J.

Vanacova, Stepanka

Villalvazo, Maria

Haas, Brian J.

Pertea, Mihaela

Feldblyum, Tamara V.

Utterback, Terry R.

Shu, Chung-Li

Osoegawa, Kazutoyo

de Jong, Pieter J.

Hrdy, Ivan

Horvathova, Lenka

Zubacova, Zuzana

Dolezal, Pavel

Malik, Shehre-Banoo

Logsdon, John M., Jr.

Henze, Katrin

Gupta, Arti

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

[2] Univ Newcastle, Div Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Maryland, Ctr Bioinformat & Computat Biol, College Pk, MD 20742 USA

[4] Univ Glasgow, Wellcome Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland

[5] Univ Glasgow, Div Infect & Immun, Glasgow Biomed Res Ctr, Glasgow G12 8TA, Lanark, Scotland

[6] Tech Univ Denmark, Ctr Biol Sequence Anal, Biocentrum DTU, DK-2800 Lyngby, Denmark

[7] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada

[8] Nat Hist Museum, Dept Zool, London SW7 5BD, England

[9] Univ Antwerp VIB, Dept Plant Syst Biol, B-9052 Ghent, Belgium

[10] Univ Dundee, Sch Life Sci Res, Dundee DD1 5EH, Scotland

[11] Univ Sassari, Dept Biomed Sci, Div Exptl & Clin Microbiol, I-07100 Sassari, Italy

[12] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

[13] J Craig Venter Joint Technol Ctr, Rockville, MD 20850 USA

[14] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA

[15] Charles Univ Prague, Dept Parasitol, Fac Sci, CR-12844 Prague, Czech Republic

[16] Univ Iowa, Dept Biol Sci, Roy J Carver Ctr Comparat Genom, Iowa City, IA 52242 USA

[17] Univ Dusseldorf, Inst Bot, D-402225 Dusseldorf, Germany

[18] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[19] Univ Queensland, Dept Microbiol & Parasitol, Brisbane, Qld 4072, Australia

[20] Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[21] Chang Gung Univ, Bioinformat Ctr, Mol Med Res Ctr, Tao Yuan 333, Taiwan

[22] Chang Gung Mem Hosp, Mol Infect Dis Res Ctr, Tao Yuan 333, Taiwan

[23] Chang Gung Mem Hosp, Med Genom Ctr, Tao Yuan 333, Taiwan

[24] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

来源：

SCIENCE | 2007年 / 315卷 / 5809期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1126/science.1132894

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the similar to 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

引用

页码：207 / 212

页数：6

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[1] The new higher level classification of eukaryotes with emphasis on the taxonomy of protists [J].