Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment

被引：75

作者：

Franke, Cornelia

Noeldner, Michael

Abdel-Kader, Reham

Johnson-Anuna, Leslie N.

Wood, W. Gibson

Mueller, Walter E.

Eckert, Gunter P.

机构：

[1] Univ Frankfurt, Bioctr, Dept Pharmacol, ZAFES, D-6000 Frankfurt, Germany

[2] Dr Willmar Schwabe Grp, Karlsruhe, Germany

[3] Univ Minnesota, Dept Pharmacol, Sch Med & Geriatr Res, Educ & Clin Ctr,Vet Affairs Med Ctr, Minneapolis, MN 55455 USA

来源：

NEUROBIOLOGY OF DISEASE | 2007年 / 25卷 / 02期

关键词：

simvastatin; neuroprotection; guinea pigs; Bcl-2; Bax; HA; 14-1; SNP;

D O I：

10.1016/j.nbd.2006.10.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bel-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 levels were significantly increased in brains of simvastatin-treated guinea pigs while levels of the proapoptotic protein Bax were significantly reduced. The ratio of Bax/Bcl-2, being a critical factor of the apoptotic state of cells, was significantly reduced in simvastatin-treated animals. Cholesterol levels in the brain remained unchanged in the simvastatin group. Brain cells isolated from simvastatin-treated guinea pigs were significantly less vulnerable to mitochondrial dysfunction and caspase-activation. These results provide new insight into potential mechanisms for the protective actions of statins within the CNS where programmed cell death has been implicated. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：438 / 445

页数：8

共 56 条

[1] The dynamics of statins - From event prevention to neuroprotection [J].