Design of a G-Quadruplex Topology through Glycosidic Bond Angles

被引：66

作者：

da Silva, Mateus Webba ^{[1
,2
]}

Trajkovski, Marko ^{[3
]}

Sannohe, Yuta ^{[5
]}

Hessari, Nason Ma'ani ^{[1
]}

Sugiyama, Hiroshi ^{[5
,6
]}

Plavec, Janez ^{[3
,4
]}

机构：

[1] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[2] Univ Ulster, Biomed Sci Res Inst, Coleraine BT52 1SA, Londonderry, North Ireland

[3] Slovenian NMR Ctr, Natl Inst Chem, Ljubljana 1000, Slovenia

[4] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia

[5] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068501, Japan

[6] Kyoto Univ, Inst Integrated Cell Mat Sci, Kyoto 6068501, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 48期

关键词：

glycosidic bonds; G quadruplexes; quadruplex folding; self-assembly; topology; STABILITY;

D O I：

10.1002/anie.200902454

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Building regulations: Thus far the discovery of novel DNA quadruplex topologies was either serendipitous or through coincidental emergence. Now a deductive system, based on the glycosidic bond angle of guanosines, can be used to derive a set of inference rules for the prediction of both known and theoretical quadruplex topologies. This formalism was used to design and control the self-assembly of a novel DNA quadruplex architecture. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：9167 / 9170

页数：4

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