Regulation of immunity and oncogenesis by the IRF transcription factor family

被引：343

作者：

Savitsky, David ^{[1
]}

Tamura, Tomohiko ^{[1
]}

Yanai, Hideyuki ^{[1
]}

Taniguchi, Tadatsugu ^{[1
]}

机构：

[1] Univ Tokyo, Dept Immunol, Fac Med, Grad Sch Med,Bunkyo Ku, Tokyo 1130033, Japan

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2010年 / 59卷 / 04期

关键词：

Interferon regulatory factor; Host defense; Transcriptional regulation; Immunity; Oncogenesis; SEQUENCE-BINDING-PROTEIN; TOLL-LIKE RECEPTORS; DENDRITIC CELL-DEVELOPMENT; ANTIVIRAL INNATE IMMUNITY; CHRONIC MYELOID-LEUKEMIA; EPSTEIN-BARR-VIRUS; NF-KAPPA-B; STIMULATED RESPONSE ELEMENT; INDUCED GROWTH SUPPRESSION; HEMATOPOIETIC STEM-CELLS;

D O I：

10.1007/s00262-009-0804-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.

引用

页码：489 / 510

页数：22

共 227 条

[1]

Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2]

Essential role for ICSBP in the in vivo development of murine CD8α+ dendritic cells [J].

Aliberti, J ;

Schulz, O ;

Pennington, DJ ;

Tsujimura, H ;

Sousa, CRE ;

Ozato, K ;

Sher, A .

BLOOD, 2003, 101 (01) :305-310

[3]

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter [J].

Andrejeva, J ;

Childs, KS ;

Young, DF ;

Carlos, TS ;

Stock, N ;

Goodbourn, S ;

Randall, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17264-17269

[4]

IRF6 in development and disease - A mediator of quiescence and differentiation [J].

Bailey, Caleb M. ;

Hendrix, Mary J. C. .

CELL CYCLE, 2008, 7 (13) :1925-1930

[5]

Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner [J].

Bailey, Caleb M. ;

Abbott, Daniel E. ;

Margaryan, Naira V. ;

Khalkhali-Ellis, Zhila ;

Hendrix, Mary J. C. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (07) :2235-2243

[6]

Functional Regulation of MyD88-Activated Interferon Regulatory Factor 5 by K63-Linked Polyubiquitination [J].

Balkhi, Mumtaz Yaseen ;

Fitzgerald, Katherine A. ;

Pitha, Paula M. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (24) :7296-7308

[7]

Barnes BJ, 2003, CANCER RES, V63, P6424

[8]

Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes [J].

Barnes, BJ ;

Field, AE ;

Pitha-Rowe, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :16630-16641

[9]

Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7 [J].

Barro, Mario ;

Patton, John T. .

JOURNAL OF VIROLOGY, 2007, 81 (09) :4473-4481

[10]

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4 [J].

Bruestle, Anne ;

Heink, Sylvia ;

Huber, Magdalena ;

Rosenplaenter, Christine ;

Stadelmann, Christine ;

Yu, Philipp ;

Arpaia, Enrico ;

Mak, Tak W. ;

Kamradt, Thomas ;

Lohoff, Michael .

NATURE IMMUNOLOGY, 2007, 8 (09) :958-966

← 1 2 3 4 5 6 7 8 9 10 →