Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population

被引：31

作者：

An, Yu ^{[2
,3
]}

Jin, Guangfu ^{[4
]}

Wang, Haifeng ^{[1
]}

Wang, Yi ^{[1
,2
,3
]}

Liu, Hongliang ^{[2
,3
]}

Li, Rui ^{[2
,3
]}

Wang, Haijian ^{[2
,3
]}

Qian, Ji ^{[2
,3
]}

Sun, Weiwei ^{[1
]}

Wang, Yi ^{[1
,2
,3
]}

Ma, Hongxia ^{[4
]}

Miao, Ruifeng ^{[4
]}

Hu, Zhibin ^{[4
]}

Jin, Li ^{[2
,3
]}

Wei, Qingyi ^{[5
]}

Shen, Hongbing ^{[4
]}

Huang, Wei ^{[1
]}

Lu, Daru ^{[2
,3
]}

机构：

[1] Chinese Natl Human Genome Ctr Shanghai, Dept Genet, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[3] Fudan Univ, Sch Life Sci, MOE Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

[4] Nanjing Med Univ, Canc Res Ctr, Dept Epidemiol & Biostat, Nanjing, Peoples R China

[5] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX USA

来源：

LUNG CANCER | 2008年 / 59卷 / 02期

关键词：

hMLH1; genetic polymorphisms; lung cancer; susceptibility; molecular epidemiology;

D O I：

10.1016/j.lungcan.2007.08.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA mismatch repair (MMR) plays an important role in maintaining genome stability. Defects in MMR genes have been involved in several types of sporadic and hereditary cancers. hMLH1 is considered one of central members of the MMR pathway. We conducted a hospital-based case-control study to investigate associations of common variations in the hMLH1 gene and risk of lung cancer. A total of 500 cases and 517 controls were genotyped for seven SNPs in hMLH1. Overall, the rs1799977 I219V polymorphism was marginally associated with the risk of lung cancer (P=0.055). This association was much stronger in younger patients (P=0.01; odds ratio, 5.28; 95% CI 1.45-19.21) and lung squamous cell carcinoma (P=0.006; odds ratio, 3.65; 95% CI 1.44-9.24). These findings indicate that the hMLH1 rs1799977 polymorphism may contribute to the etiology of early-onset lung cancer as well as some specific subtype of lung cancer. Larger association studies are warranted to validate our findings and mechanistic studies are needed to elucidate the underlying molecular mechanisms of the association. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：164 / 170

页数：7

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