A novel strategy for the enantioselective synthesis of the steroidal framework using cascade ring expansion reactions of small ring systems - Asymmetric total synthesis of (+)-equilenin

被引：37

作者：

Nemoto, H ^{[1
]}

Yoshida, M ^{[1
]}

Fukumoto, K ^{[1
]}

Ihara, M ^{[1
]}

机构：

[1] Tohoku Univ, Inst Pharmaceut, Sendai, Miyagi 9808578, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

asymmetric synthesis; rearrangement; steroids and sterols; stereocontrol;

D O I：

10.1016/S0040-4039(98)02479-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of (+)-equilenin (1) utilizing a novel strategy is described. The key steps are two cascade ring expansion reactions of small ring systems; 1) chiral (salen)Mn-III complex-catalyzed cascade reaction of cyclopropylidene; 2) Pd-II-mediated cascade reaction of the cyclobutanol. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：907 / 910

页数：4

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