Corridors of migrating neurons in the human brain and their decline during infancy

被引:659
作者
Sanai, Nader [1 ,2 ,3 ,4 ]
Thuhien Nguyen [1 ,2 ]
Ihrie, Rebecca A. [1 ,2 ]
Mirzadeh, Zaman [1 ,2 ,4 ]
Tsai, Hui-Hsin [1 ,2 ]
Wong, Michael [1 ,2 ]
Gupta, Nalin [3 ]
Berger, Mitchel S. [3 ]
Huang, Eric [5 ]
Garcia-Verdugo, Jose-Manuel [6 ]
Rowitch, David H. [1 ,2 ,3 ,7 ]
Alvarez-Buylla, Arturo [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Eli & Edythe Broad Inst Regenerat Med & Stem Cell, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[4] Barrow Neurol Inst, Barrow Brain Tumor Res Ctr, Phoenix, AZ 85013 USA
[5] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[6] CIBERNED, Unidad Mixta CIPF UVEG, Lab Morfol Celular, Valencia 46012, Spain
[7] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA
关键词
NEURAL STEM-CELLS; VENTROMEDIAL PREFRONTAL CORTEX; SUBVENTRICULAR ZONE; OLFACTORY-BULB; ADULT NEUROGENESIS; LATERAL VENTRICLE; PLASTICITY; FOREBRAIN; NEUROBLASTS; EPENDYMA;
D O I
10.1038/nature10487
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
The subventricular zone of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb(1-6). Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially oriented chains that coalesce into a rostral migratory stream (RMS) connecting the subventricular zone to the olfactory bulb. The adult human subventricular zone, in contrast, contains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astrocytes(7). Some of these subventricular zone astrocytes can function as neural stem cells in vitro, but their function in vivo remains controversial. An initial report found few subventricular zone proliferating cells and rare migrating immature neurons in the RMS of adult humans(7). In contrast, a subsequent study indicated robust proliferation and migration in the human subventricular zone and RMS8,9. Here we find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports(8), this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited window of neurogenesis, not all new neurons in the human subventricular zone are destined for the olfactory bulb-we describe a major migratory pathway that targets the prefrontal cortex in humans. Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates.
引用
收藏
页码:382 / +
页数:6
相关论文
共 32 条
[1]
The rostral migratory stream in adult squirrel monkeys:: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl-2 [J].
Bédard, A ;
Lévesque, M ;
Bernier, PJ ;
Parent, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 16 (10) :1917-1924
[2]
SUBEPENDYMAL PLATE AND ASSOCIATED EPENDYMA IN DOG - ULTRASTRUCTURAL STUDY [J].
BLAKEMORE, WF ;
JOLLY, RD .
JOURNAL OF NEUROCYTOLOGY, 1972, 1 (01) :69-84
[3]
Olfactory Enrichment Influences Adult Neurogenesis Modulating GAD67 and Plasticity-Related Molecules Expression in Newborn Cells of the Olfactory Bulb [J].
Bovetti, Serena ;
Veyrac, Alexandra ;
Peretto, Paolo ;
Fasolo, Aldo ;
De Marchis, Silvia .
PLOS ONE, 2009, 4 (07)
[4]
Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension [J].
Curtis, Maurice A. ;
Kam, Monica ;
Nannmark, Ulf ;
Anderson, Michelle F. ;
Axell, Mathilda Zetterstrom ;
Wikkelso, Carsten ;
Holtas, Stig ;
van Roon-Mom, Willeke M. C. ;
Bjork-Eriksson, Thomas ;
Nordborg, Claes ;
Frisen, Jonas ;
Dragunow, Michael ;
Faull, Richard L. M. ;
Eriksson, Peter S. .
SCIENCE, 2007, 315 (5816) :1243-1249
[5]
EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells [J].
Doetsch, F ;
Petreanu, L ;
Caille, I ;
Garcia-Verdugo, JM ;
Alvarez-Buylla, A .
NEURON, 2002, 36 (06) :1021-1034
[6]
Cytoarchitecture of the Lateral Ganglionic Eminence and Rostral Extension of the Lateral Ventricle in the Human Fetal Brain [J].
Guerrero-Cazares, Hugo ;
Gonzalez-Perez, Oscar ;
Soriano-Navarro, Mario ;
Zamora-Berridi, Grettel ;
Manuel Garcia-Verdugo, Jose ;
Quinones-Hinojosa, Alfredo .
JOURNAL OF COMPARATIVE NEUROLOGY, 2011, 519 (06) :1165-1180
[7]
Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET [J].
Herholz, K ;
Salmon, E ;
Perani, D ;
Baron, JC ;
Holthoff, V ;
Frölich, L ;
Schönknecht, P ;
Ito, K ;
Mielke, R ;
Kalbe, E ;
Zündorf, G ;
Delbeuck, X ;
Pelati, O ;
Anchisi, D ;
Fazio, F ;
Kerrouche, N ;
Desgranges, B ;
Eustache, F ;
Beuthien-Baumann, B ;
Menzel, C ;
Schröder, J ;
Kato, T ;
Arahata, Y ;
Henze, M ;
Heiss, WD .
NEUROIMAGE, 2002, 17 (01) :302-316
[8]
The development of the olfactory and the accessory olfactory formations in human embryos and fetuses [J].
Humphrey, T .
JOURNAL OF COMPARATIVE NEUROLOGY, 1940, 73 (03) :431-468
[9]
The generation, migration, and differentiation of olfactory neurons in the adult primate brain [J].
Kornack, DR ;
Rakic, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4752-4757
[10]
Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain [J].
Kuan, CY ;
Schloemer, AJ ;
Lu, AG ;
Burns, KA ;
Weng, WL ;
Williams, MT ;
Strauss, KI ;
Vorhees, CV ;
Flavell, RA ;
Davis, RJ ;
Sharp, FR ;
Rakic, P .
JOURNAL OF NEUROSCIENCE, 2004, 24 (47) :10763-10772