Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

被引：23

作者：

Anikeeva, Nadia ^{[1
,2
]}

Sykulev, Yuri ^{[1
,2
]}

机构：

[1] Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Jefferson Vaccine Ctr, Philadelphia, PA 19107 USA

来源：

IMMUNOLOGIC RESEARCH | 2011年 / 51卷 / 2-3期

关键词：

Cytotoxic lymphocytes; T-cell receptor; Signaling kinetics; Cytolytic granules; Cytolytic synapse; Efficiency of target cell lysis; PEPTIDE-MHC COMPLEXES; CELL ANTIGEN RECEPTOR; CLASS-I COMPLEXES; SUPRAMOLECULAR ACTIVATION CLUSTERS; IMMUNOLOGICAL SYNAPSE; MHC/PEPTIDE COMPLEXES; SECRETORY DOMAIN; STRUCTURAL BASIS; RING JUNCTION; BOUND PEPTIDE;

D O I：

10.1007/s12026-011-8252-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cytotoxic T lymphocytes (CTL) play a critical role in immunity against viruses and cancer. The antigen receptor or T-cell receptor (TCR) on CTL determines the specificity toward target cells. The CD8 co-receptor functions in concert with the TCR to enhance TCR-mediated signaling, accounting for the remarkable sensitivity and swift signaling kinetics of the CTL response. The latter ensures efficient delivery and release of lytic granules, resulting in sensitive and rapid destruction of target cells.

引用

收藏

页码：183 / 194

页数：12

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